TY - GEN
T1 - Influence of shell-thickness-to-radius ratio on buckling and rupture of polymer-shelled ultrasound contrast agents
AU - Koppolu, Sujeethraj
AU - Chitnis, Parag V.
AU - Mamou, Jonathan
AU - Ketterling, Jeffrey A.
AU - Allen, John S.
PY - 2012
Y1 - 2012
N2 - This study investigated the behavior of polymer-shelled ultrasound contrast agents (UCAs) of different shell-thickness-to-radius ratios (STRRs) when subjected to static overpressure. Three varieties of polylactide shelled UCAs with STRRs of 7.5, 40 and 100 nm/μm were studied. A custom-designed pressure chamber was employed to observe polymer-shelled UCAs through a video microscope. A normalized cross-sectional area of individual UCAs was obtained from the binarized UCA images. Integration of the normalized cross-sectional area over time, defined as Buckling factor (Bf), provided a dimensionless parameter to compare the differences between the buckling behaviors of UCAs with different STRRs. The UCAs with an STRR of 7.5 nm/μm exhibited a distinct buckling behavior prior to shell rupture (Bf<1), whereas the UCAs with higher STRRs (40 and 100 nm/μm) did not undergo significant pre-rupture buckling (Bf≈1). The observed behavior was in agreement with a recently reported mathematical model and qualitatively consistent with the experimentally observed behavior of UCAs subjected to ultrasound.
AB - This study investigated the behavior of polymer-shelled ultrasound contrast agents (UCAs) of different shell-thickness-to-radius ratios (STRRs) when subjected to static overpressure. Three varieties of polylactide shelled UCAs with STRRs of 7.5, 40 and 100 nm/μm were studied. A custom-designed pressure chamber was employed to observe polymer-shelled UCAs through a video microscope. A normalized cross-sectional area of individual UCAs was obtained from the binarized UCA images. Integration of the normalized cross-sectional area over time, defined as Buckling factor (Bf), provided a dimensionless parameter to compare the differences between the buckling behaviors of UCAs with different STRRs. The UCAs with an STRR of 7.5 nm/μm exhibited a distinct buckling behavior prior to shell rupture (Bf<1), whereas the UCAs with higher STRRs (40 and 100 nm/μm) did not undergo significant pre-rupture buckling (Bf≈1). The observed behavior was in agreement with a recently reported mathematical model and qualitatively consistent with the experimentally observed behavior of UCAs subjected to ultrasound.
UR - https://www.scopus.com/pages/publications/84882365974
U2 - 10.1109/ULTSYM.2012.0098
DO - 10.1109/ULTSYM.2012.0098
M3 - Conference contribution
AN - SCOPUS:84882365974
SN - 9781467345613
T3 - IEEE International Ultrasonics Symposium, IUS
SP - 398
EP - 401
BT - 2012 IEEE International Ultrasonics Symposium, IUS 2012
T2 - 2012 IEEE International Ultrasonics Symposium, IUS 2012
Y2 - 7 October 2012 through 10 October 2012
ER -