Influence of shear rate on platelet aggregation in cerebral microvessels

William I. Rosenblum, Farouk El-Sabban

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The aggregation of platelets in injured cerebral arterioles was delayed as the wall shear rate rose, over a range of 0.2 to 1.4 sec-1. The shear rates were calculated from centerline velocities determined with the two-slit technique and a cross correlator. The velocity range was 2 to 13 mm/sec. The correlation between aggregation latency and shear rate was 0.44, P < 0.02, and 0.55, P < 0.05, in each of two studies. The correlation between aggregation latency and centerline velocity was slightly less and was slightly less significant than the correlation between shear rate and aggregation latency.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalMicrovascular Research
Volume23
Issue number3
DOIs
StatePublished - May 1982
Externally publishedYes

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