TY - JOUR
T1 - Influence of shear rate on platelet aggregation in cerebral microvessels
AU - Rosenblum, William I.
AU - El-Sabban, Farouk
N1 - Funding Information:
Supported by Public Health Service Grant HL-23560. 2 Reprint requests to Dr. Rosenblum, Box 17, MCV Station, Richmond, VA. 23298.
PY - 1982/5
Y1 - 1982/5
N2 - The aggregation of platelets in injured cerebral arterioles was delayed as the wall shear rate rose, over a range of 0.2 to 1.4 sec-1. The shear rates were calculated from centerline velocities determined with the two-slit technique and a cross correlator. The velocity range was 2 to 13 mm/sec. The correlation between aggregation latency and shear rate was 0.44, P < 0.02, and 0.55, P < 0.05, in each of two studies. The correlation between aggregation latency and centerline velocity was slightly less and was slightly less significant than the correlation between shear rate and aggregation latency.
AB - The aggregation of platelets in injured cerebral arterioles was delayed as the wall shear rate rose, over a range of 0.2 to 1.4 sec-1. The shear rates were calculated from centerline velocities determined with the two-slit technique and a cross correlator. The velocity range was 2 to 13 mm/sec. The correlation between aggregation latency and shear rate was 0.44, P < 0.02, and 0.55, P < 0.05, in each of two studies. The correlation between aggregation latency and centerline velocity was slightly less and was slightly less significant than the correlation between shear rate and aggregation latency.
UR - http://www.scopus.com/inward/record.url?scp=0020055708&partnerID=8YFLogxK
U2 - 10.1016/S0026-2862(82)80003-4
DO - 10.1016/S0026-2862(82)80003-4
M3 - Article
C2 - 7099021
AN - SCOPUS:0020055708
SN - 0026-2862
VL - 23
SP - 311
EP - 315
JO - Microvascular Research
JF - Microvascular Research
IS - 3
ER -