TY - JOUR
T1 - Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression
AU - Mendlewicz, Julien
AU - Crisafulli, Concetta
AU - Calati, Raffaella
AU - Kocabas, Neslihan Aygun
AU - Massat, Isabelle
AU - Linotte, Sylvie
AU - Kasper, Siegfried
AU - Fink, Martin
AU - Sidoti, Antonina
AU - Scantamburlo, Gabrielle
AU - Ansseau, Marc
AU - Antonijevic, Irina
AU - Forray, Carlos
AU - Snyder, Lenore
AU - Bollen, Joseph
AU - Montgomery, Stuart
AU - Zohar, Joseph
AU - Souery, Daniel
AU - Serretti, Alessandro
PY - 2012/5/10
Y1 - 2012/5/10
N2 - Inflammatory pathways play a crucial role in the pathomechanisms of antidepressant efficacy. The aim of this study was to investigate whether a set of single nucleotide polymorphisms (SNPs) within cyclooxygenase-2 (. COX-2, rs5275 and rs20417) and oxytocin receptor (. OXTR, rs53576 and rs2254298) genes was associated with antidepressant treatment resistance, response or remission. Three hundred seventy-two patients were recruited in the context of a multicenter resistant depression study. They were genotyped for . COX-2 and . OXTR SNPs. Treatment resistance (according to two different definitions), response and remission were recorded. We did not observe any association between the genotypes or alleles of the selected SNPs within . COX-2 and . OXTR genes and treatment resistance, response and remission in the whole sample. Our results are consistent with those of some studies but not with those of other ones. Indeed, several factors could be involved in the discrepancy observed across studies. They include sample size, environmental factors, differences in ethnicity, different study designs, and different definitions of treatment resistance.
AB - Inflammatory pathways play a crucial role in the pathomechanisms of antidepressant efficacy. The aim of this study was to investigate whether a set of single nucleotide polymorphisms (SNPs) within cyclooxygenase-2 (. COX-2, rs5275 and rs20417) and oxytocin receptor (. OXTR, rs53576 and rs2254298) genes was associated with antidepressant treatment resistance, response or remission. Three hundred seventy-two patients were recruited in the context of a multicenter resistant depression study. They were genotyped for . COX-2 and . OXTR SNPs. Treatment resistance (according to two different definitions), response and remission were recorded. We did not observe any association between the genotypes or alleles of the selected SNPs within . COX-2 and . OXTR genes and treatment resistance, response and remission in the whole sample. Our results are consistent with those of some studies but not with those of other ones. Indeed, several factors could be involved in the discrepancy observed across studies. They include sample size, environmental factors, differences in ethnicity, different study designs, and different definitions of treatment resistance.
KW - Antidepressants
KW - Bipolar disorder
KW - COX-2
KW - Major depression
KW - OXTR
UR - http://www.scopus.com/inward/record.url?scp=84860250106&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2012.03.063
DO - 10.1016/j.neulet.2012.03.063
M3 - Article
C2 - 22487732
AN - SCOPUS:84860250106
SN - 0304-3940
VL - 516
SP - 85
EP - 88
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -