TY - JOUR
T1 - Inflammatory Diseases of the Aorta
T2 - JACC Focus Seminar, Part 2
AU - Kadian-Dodov, Daniella
AU - Seo, Philip
AU - Robson, Philip M.
AU - Fayad, Zahi A.
AU - Olin, Jeffrey W.
N1 - Publisher Copyright:
© 2022 American College of Cardiology Foundation
PY - 2022/8/23
Y1 - 2022/8/23
N2 - Inflammatory aortitis is most often caused by large vessel vasculitis (LVV), including giant cell arteritis, Takayasu's arteritis, immunoglobulin G4–related aortitis, and isolated aortitis. There are distinct differences in the clinical presentation, imaging findings, and natural history of LVV that are important for the cardiovascular provider to know. If possible, histopathologic specimens should be obtained to aide in accurate diagnosis and management of LVV. In most cases, corticosteroids are utilized in the acute phase, with the addition of steroid-sparing agents to achieve disease remission while sparing corticosteroid toxic effects. Endovascular and surgical procedures have been described with success but should be delayed until disease control is achieved whenever possible. Long-term management should include regular follow-up with rheumatology and surveillance imaging for sequelae of LVV.
AB - Inflammatory aortitis is most often caused by large vessel vasculitis (LVV), including giant cell arteritis, Takayasu's arteritis, immunoglobulin G4–related aortitis, and isolated aortitis. There are distinct differences in the clinical presentation, imaging findings, and natural history of LVV that are important for the cardiovascular provider to know. If possible, histopathologic specimens should be obtained to aide in accurate diagnosis and management of LVV. In most cases, corticosteroids are utilized in the acute phase, with the addition of steroid-sparing agents to achieve disease remission while sparing corticosteroid toxic effects. Endovascular and surgical procedures have been described with success but should be delayed until disease control is achieved whenever possible. Long-term management should include regular follow-up with rheumatology and surveillance imaging for sequelae of LVV.
KW - aneurysm
KW - aortitis
KW - dissection
KW - large vessel vasculitis
UR - http://www.scopus.com/inward/record.url?scp=85135716882&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2022.05.046
DO - 10.1016/j.jacc.2022.05.046
M3 - Review article
AN - SCOPUS:85135716882
SN - 0735-1097
VL - 80
SP - 832
EP - 844
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 8
ER -