Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn's Disease

Ron Palmon, Lloyd F. Mayer

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Inflammatory bowel disease (IBD) is a complex, multifactorial disease with a wide range of clinical presentations and complications. IBD is divided into two distinct but related entities: Crohn's disease (CD) and ulcerative colitis (UC). While the two diseases share some features, there are important clinical differences between them, and they are discussed in this chapter. The pathogenesis of IBD appears to represent an abnormal response by T-cells to normal gastrointestinal flora on a genetically susceptible background. The medical treatment of IBD involves a growing armamentarium of medications, as a fundamental knowledge of disease pathogenesis expands. Many of these drugs are used for both UC and CD. Clinical trials are hampered by a consistent finding of placebo response rates of about 30%. Some of the major classes of medication are presented with specific mention of their use in CD and UC. Further research undoubtedly lead to better treatment and perhaps even cure or prevention of disease.

Original languageEnglish
Title of host publicationThe Autoimmune Diseases, Fourth Edition
PublisherElsevier
Pages713,XXII-728,XXIII
ISBN (Electronic)9780125959612
DOIs
StatePublished - 1 Jan 2006

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