TY - JOUR
T1 - Inflammatory biomarkers as predictors of heart failure in women without obstructive coronary artery disease
T2 - A report from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE)
AU - Al Badri, Ahmed
AU - Lai, Kha
AU - Wei, Janet
AU - Landes, Sofy
AU - Mehta, Puja K.
AU - Li, Quanlin
AU - Johnson, Delia
AU - Reis, Steven E.
AU - Kelsey, Sheryl F.
AU - Bittner, Vera
AU - Sopko, George
AU - Shaw, Leslee J.
AU - Pepine, Carl J.
AU - Merz, C. Noel Bairey
N1 - Publisher Copyright:
© 2017 AlBadri et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2017/5
Y1 - 2017/5
N2 - Background: Women with signs and symptoms of ischemia, no obstructive coronary artery disease (CAD) and preserved left ventricular ejection fraction (EF) often have diastolic dysfunction and experience elevated rates of major adverse cardiac events (MACE), including heart failure (HF) hospitalization with preserved ejection fraction (HFpEF). We evaluated the predictive value of inflammatory biomarkers for long-term HF hospitalization and all-cause mortality in these women. Methods: We performed a cross-sectional analysis to investigate the relationships between inflammatory biomarkers [serum interleukin-6 (IL-6), C-reactive protein (hs-CRP) and serum amyloid A (SAA)] and median of 6 years follow-up for all-cause mortality and HF hospitalization among women with signs and symptoms of ischemia, non-obstructive CAD and preserved EF. Multivariable Cox regression analysis tested associations between biomarker levels and adverse outcomes. Results: Among 390 women, mean age 56 ±11 years, median follow up of 6 years, we observed that there is continuous association between IL-6 level and HF hospitalization (adjusted hazard ratio [AHR] 2.5 [1.2-5.0], p = 0.02). In addition, we found significant association between IL-6, SAA levels and all-cause mortality AHR (1.8 [1.1-3.0], p = 0.01) (1.5 [1.0-2.1], p = 0.04), respectively.
AB - Background: Women with signs and symptoms of ischemia, no obstructive coronary artery disease (CAD) and preserved left ventricular ejection fraction (EF) often have diastolic dysfunction and experience elevated rates of major adverse cardiac events (MACE), including heart failure (HF) hospitalization with preserved ejection fraction (HFpEF). We evaluated the predictive value of inflammatory biomarkers for long-term HF hospitalization and all-cause mortality in these women. Methods: We performed a cross-sectional analysis to investigate the relationships between inflammatory biomarkers [serum interleukin-6 (IL-6), C-reactive protein (hs-CRP) and serum amyloid A (SAA)] and median of 6 years follow-up for all-cause mortality and HF hospitalization among women with signs and symptoms of ischemia, non-obstructive CAD and preserved EF. Multivariable Cox regression analysis tested associations between biomarker levels and adverse outcomes. Results: Among 390 women, mean age 56 ±11 years, median follow up of 6 years, we observed that there is continuous association between IL-6 level and HF hospitalization (adjusted hazard ratio [AHR] 2.5 [1.2-5.0], p = 0.02). In addition, we found significant association between IL-6, SAA levels and all-cause mortality AHR (1.8 [1.1-3.0], p = 0.01) (1.5 [1.0-2.1], p = 0.04), respectively.
UR - https://www.scopus.com/pages/publications/85019350582
U2 - 10.1371/journal.pone.0177684
DO - 10.1371/journal.pone.0177684
M3 - Article
C2 - 28542263
AN - SCOPUS:85019350582
SN - 1932-6203
VL - 12
JO - PLoS ONE
JF - PLoS ONE
IS - 5
M1 - e0177684
ER -