Inflammation in coronary artery disease

Georgios Christodoulidis, Timothy J. Vittorio, Marat Fudim, Stamatios Lerakis, Constantine E. Kosmas

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations

Abstract

Coronary artery disease (CAD) is the leading cause of death in the United States. Although CAD was formerly considered a lipid accumulation-mediated disease, it has now been clearly shown to involve an ongoing inflammatory response. Advances in basic science research have established the crucial role of inflammation in mediating all stages of CAD. Today, there is convincing evidence that multiple interrelated immune mechanisms interact with metabolic risk factors to initiate, promote, and ultimately activate lesions in the coronary arteries. This review aims to provide current evidence pertaining to the role of inflammation in the pathogenesis of CAD and discusses the impact of inflammatory markers and their modification on clinical outcomes.

Original languageEnglish
Pages (from-to)279-288
Number of pages10
JournalCardiology in Review
Volume22
Issue number6
DOIs
StatePublished - 2014

Keywords

  • Acute-phase response
  • Atherosclerosis
  • Chemokines
  • Cytokines
  • Inflammatory markers
  • Pathogenesis
  • Proliferation

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