Inflammation, Immunity, and Infection in Atherothrombosis: JACC Review Topic of the Week

Peter Libby, Joseph Loscalzo, Paul M. Ridker, Michael E. Farkouh, Priscilla Y. Hsue, Valentin Fuster, Ahmed A. Hasan, Salomon Amar

Research output: Contribution to journalReview articlepeer-review

383 Scopus citations

Abstract

Observations on human and experimental atherosclerosis, biomarker studies, and now a large-scale clinical trial support the operation of immune and inflammatory pathways in this disease. The factors that incite innate and adaptive immune responses implicated in atherogenesis and in lesion complication include traditional risk factors such as protein and lipid components of native and modified low-density lipoprotein, angiotensin II, smoking, visceral adipose tissue, and dysmetabolism. Infectious processes and products of the endogenous microbiome might also modulate atherosclerosis and its complications either directly, or indirectly by eliciting local and systemic responses that potentiate disease expression. Trials with antibiotics have not reduced recurrent cardiovascular events, nor have vaccination strategies yet achieved clinical translation. However, anti-inflammatory interventions such as anticytokine therapy and colchicine have begun to show efficacy in this regard. Thus, inflammatory and immune mechanisms can link traditional and emerging risk factors to atherosclerosis, and offer novel avenues for therapeutic intervention.

Original languageEnglish
Pages (from-to)2071-2081
Number of pages11
JournalJournal of the American College of Cardiology
Volume72
Issue number17
DOIs
StatePublished - 23 Oct 2018

Keywords

  • basic & translational research

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