TY - JOUR
T1 - Inflammation and aging-related disease
T2 - A transdisciplinary inflammaging framework
AU - Andonian, Brian J.
AU - Hippensteel, Joseph A.
AU - Abuabara, Katrina
AU - Boyle, Eileen M.
AU - Colbert, James F.
AU - Devinney, Michael J.
AU - Faye, Adam S.
AU - Kochar, Bharati
AU - Lee, Jiha
AU - Litke, Rachel
AU - Nair, Devika
AU - Sattui, Sebastian E.
AU - Sheshadri, Anoop
AU - Sherman, Andrea N.
AU - Singh, Namrata
AU - Zhang, Yinan
AU - LaHue, Sara C.
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to American Aging Association 2024.
PY - 2024
Y1 - 2024
N2 - Inflammaging, a state of chronic, progressive low-grade inflammation during aging, is associated with several adverse clinical outcomes, including frailty, disability, and death. Chronic inflammation is a hallmark of aging and is linked to the pathogenesis of many aging-related diseases. Anti-inflammatory therapies are also increasingly being studied as potential anti-aging treatments, and clinical trials have shown benefits in selected aging-related diseases. Despite promising advances, significant gaps remain in defining, measuring, treating, and integrating inflammaging into clinical geroscience research. The Clin-STAR Inflammation Research Interest Group was formed by a group of transdisciplinary clinician-scientists with the goal of advancing inflammaging-related clinical research and improving patient-centered care for older adults. Here, we integrate insights from nine medical subspecialties to illustrate the widespread impact of inflammaging on diseases linked to aging, highlighting the extensive opportunities for targeted interventions. We then propose a transdisciplinary approach to enhance understanding and treatment of inflammaging that aims to improve comprehensive care for our aging patients.
AB - Inflammaging, a state of chronic, progressive low-grade inflammation during aging, is associated with several adverse clinical outcomes, including frailty, disability, and death. Chronic inflammation is a hallmark of aging and is linked to the pathogenesis of many aging-related diseases. Anti-inflammatory therapies are also increasingly being studied as potential anti-aging treatments, and clinical trials have shown benefits in selected aging-related diseases. Despite promising advances, significant gaps remain in defining, measuring, treating, and integrating inflammaging into clinical geroscience research. The Clin-STAR Inflammation Research Interest Group was formed by a group of transdisciplinary clinician-scientists with the goal of advancing inflammaging-related clinical research and improving patient-centered care for older adults. Here, we integrate insights from nine medical subspecialties to illustrate the widespread impact of inflammaging on diseases linked to aging, highlighting the extensive opportunities for targeted interventions. We then propose a transdisciplinary approach to enhance understanding and treatment of inflammaging that aims to improve comprehensive care for our aging patients.
KW - Aging-related diseases
KW - Cellular senescence
KW - Geriatrics
KW - Inflammaging
KW - Internal medicine
UR - http://www.scopus.com/inward/record.url?scp=85205554054&partnerID=8YFLogxK
U2 - 10.1007/s11357-024-01364-0
DO - 10.1007/s11357-024-01364-0
M3 - Review article
C2 - 39352664
AN - SCOPUS:85205554054
SN - 2509-2715
JO - GeroScience
JF - GeroScience
ER -