Inflammation-a critical appreciation of the role of myeloid cells

Asif J. Iqbal; Edward A. Fisher; David R. Greaves

doi:10.1128/9781555819194.ch18

Inflammation-a critical appreciation of the role of myeloid cells

Asif J. Iqbal, Edward A. Fisher, David R. Greaves

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

Multicellular organisms have had to develop a rapid response to infection and tissue injury. In all animals on our planet, this involves mobilization of specialized cells to the focus of the infection or injury. This important insight was beautifully illustrated by Elie Metchnikoff, whose detailed drawings of cells being recruited to the site of injury caused by a rose thorn in a starfish embryo gave us the first glimpse of cells he termed “macrophages,” and neutrophils, which he termed “microphages." If not the first person to observe phagocytosis and leukocyte diapedesis, Metchnikoff was probably the first person to fully appreciate the role of these two important cellular processes in “natural” or innate immunity (1).

Original language	English
Title of host publication	Myeloid Cells in Health and Disease
Subtitle of host publication	A Synthesis
Publisher	wiley
Pages	325-342
Number of pages	18
ISBN (Electronic)	9781683670667
ISBN (Print)	9781555819187
DOIs	https://doi.org/10.1128/9781555819194.ch18
State	Published - 1 Jan 2017
Externally published	Yes

Keywords

Anti-tumor necrosis factor
Collagen-induced arthritis
Extra-cellular matrix
Hyaluronan
Inflammatory mediator
Mammalian hepatocyte
Myeloid cell metabolism

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10.1128/9781555819194.ch18

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KW - Collagen-induced arthritis

KW - Extra-cellular matrix

KW - Hyaluronan

KW - Inflammatory mediator

KW - Mammalian hepatocyte

KW - Myeloid cell metabolism

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Inflammation-a critical appreciation of the role of myeloid cells

Abstract

Keywords

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