Inferring stimulus selectivity from the spatial structure of neural network dynamics

Kanaka Rajan, L. F. Abbott, Haim Sompolinsky

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

8 Scopus citations

Abstract

How are the spatial patterns of spontaneous and evoked population responses related? We study the impact of connectivity on the spatial pattern of fluctuations in the input-generated response, by comparing the distribution of evoked and intrinsically generated activity across the different units of a neural network. We develop a complementary approach to principal component analysis in which separate high-variance directions are derived for each input condition. We analyze subspace angles to compute the difference between the shapes of trajectories corresponding to different network states, and the orientation of the low-dimensional subspaces that driven trajectories occupy within the full space of neuronal activity. In addition to revealing how the spatiotemporal structure of spontaneous activity affects input-evoked responses, these methods can be used to infer input selectivity induced by network dynamics from experimentally accessible measures of spontaneous activity (e.g. from voltage-or calcium-sensitive optical imaging experiments). We conclude that the absence of a detailed spatial map of afferent inputs and cortical connectivity does not limit our ability to design spatially extended stimuli that evoke strong responses.

Original languageEnglish
Title of host publicationAdvances in Neural Information Processing Systems 23
Subtitle of host publication24th Annual Conference on Neural Information Processing Systems 2010, NIPS 2010
StatePublished - 2010
Externally publishedYes
Event24th Annual Conference on Neural Information Processing Systems 2010, NIPS 2010 - Vancouver, BC, Canada
Duration: 6 Dec 20109 Dec 2010

Publication series

NameAdvances in Neural Information Processing Systems 23: 24th Annual Conference on Neural Information Processing Systems 2010, NIPS 2010

Conference

Conference24th Annual Conference on Neural Information Processing Systems 2010, NIPS 2010
Country/TerritoryCanada
CityVancouver, BC
Period6/12/109/12/10

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