Infectious mononucleosis-like syndrome probably attributable to Coxsackie A virus infection

Burke A. Cunha, Nardeen Mickail, Andrew P. Petelin

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1 Scopus citations


Infectious mononucleosis (IM) is a clinical syndrome most often attributable to Epstein-Barr virus (EBV). Characteristic clinical features of EBV IM include bilateral upper lid edema, exudative or nonexudative pharyngitis, bilateral posterior cervical adenopathy, and splenomegaly ± maculopapular rash. Laboratory features of EBV IM include atypical lymphocytes and elevated levels of serum transaminases. Leukopenia and thrombocytopenia are not uncommon. The syndrome of IM may also be attributable to other infectious diseases, eg, cytomegalovirus (CMV), human herpes virus-6 (HHV-6), or Toxoplasma gondii. Less commonly, viral hepatitis, leptospirosis, brucellosis, or parvovirus B19 may present as an IM-like infection. To the best of our knowledge, only 2 cases of IM-like infections attributable to Coxsackie B viruses (B3 and B4) have been reported. We present the first reported case of an IM-like syndrome with sore throat, fatigue, atypical lymphocytes, and elevated levels of serum transaminases likely due to Coxsackie A in an immunocompetent adult.

Original languageEnglish
Pages (from-to)522-524
Number of pages3
JournalHeart and Lung: Journal of Acute and Critical Care
Issue number5
StatePublished - Sep 2012
Externally publishedYes


  • Atypical lymphocytes
  • Coxsackie A virus
  • Infectious mononucleosis
  • Infectious mononucleosis syndrome
  • Mono-like illness


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