Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease

Cláudio R.F. Marinho, Luis N. Nuñez-Apaza, Karina R. Bortoluci, André L. Bombeiro, Daniella Z. Bucci, Marcos G. Grisotto, Luiz R. Sardinha, Christian E. Jorquera, Sergio Lira, Maria Regina D'Império Lima, José M. Álvarez

Research output: Contribution to journalShort surveypeer-review

25 Scopus citations

Abstract

The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity. This report reviews our studies with Sylvio X10/4 parasites, a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to chronic myocarditis resembling the human disease. Crown

Original languageEnglish
Pages (from-to)1037-1045
Number of pages9
JournalMicrobes and Infection
Volume11
Issue number13
DOIs
StatePublished - Nov 2009

Keywords

  • Chagas' disease
  • Heart pathology
  • Immune response
  • Parasitaemia
  • Parasite evasion
  • Sylvio X10/4 parasites
  • Trypanosoma cruzi

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