TY - JOUR
T1 - Induction of Protective Immunity against Malaria by Priming-Boosting Immunization with Recombinant Cold-Adapted Influenza and Modified Vaccinia Ankara Viruses Expressing a CD8+-T-Cell Epitope Derived from the Circumsporozoite Protein of Plasmodium yoelii
AU - González-Aseguinolaza, Gloria
AU - Nakaya, Yurie
AU - Molano, Alberto
AU - Dy, Edward
AU - Esteban, Mariano
AU - Rodríguez, Dolores
AU - Rodríguez, Juan Ramón
AU - Palese, Peter
AU - García-Sastre, Adolfo
AU - Nussenzweig, Ruth S.
PY - 2003/11
Y1 - 2003/11
N2 - We immunized mice with an attenuated (cold-adapted) influenza virus followed by an attenuated vaccinia virus (modified vaccinia virus Ankara), both expressing a CD8+-T-cell epitope derived from malaria sporozoites. This vaccination regimen elicited high levels of protection against malaria. This is the first time that the vaccine efficacy of a recombinant cold-adapted influenza virus vector expressing a foreign antigen has been evaluated.
AB - We immunized mice with an attenuated (cold-adapted) influenza virus followed by an attenuated vaccinia virus (modified vaccinia virus Ankara), both expressing a CD8+-T-cell epitope derived from malaria sporozoites. This vaccination regimen elicited high levels of protection against malaria. This is the first time that the vaccine efficacy of a recombinant cold-adapted influenza virus vector expressing a foreign antigen has been evaluated.
UR - https://www.scopus.com/pages/publications/10744227393
U2 - 10.1128/JVI.77.21.11859-11866.2003
DO - 10.1128/JVI.77.21.11859-11866.2003
M3 - Article
C2 - 14557672
AN - SCOPUS:10744227393
SN - 0022-538X
VL - 77
SP - 11859
EP - 11866
JO - Journal of Virology
JF - Journal of Virology
IS - 21
ER -