Induction of ovulation — past, present and future

Raphael Jewelewicz, Paul R. Gindoff

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Attempts to induce ovulation have been made since the early 1920s, but the major breakthrough came in the early 1960s with the introduction of clomiphene citrate and the gonadotropins. Additional progress was made in the early 1970s with the introduction of bromocriptine and in the early 1980s with the introduction of pulsatile GnRH. At the present, ‘pure’ FSH and GnRH agonists are being evaluated as adjuncts to HMG for induction of ovulation. As more insight is gained in the neuroendocrine control of the ovulating cycle, we may soon be able to induce ovulation by direct manipulation of the central nervous system.

Original languageEnglish
Pages (from-to)89-103
Number of pages15
JournalGynecologic and Obstetric Investigation
Issue number2
StatePublished - 1988
Externally publishedYes


  • Clomiphene citrate
  • Gonadotropin-releasing hormone
  • Human chorionic gonadotropins
  • Human menopausal gonadotropins
  • Opioid peptides


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