Induction of immunological memory in baboons primed with DNA vaccine as neonates

Adrian Bot, Michael Shearer, Simona Bot, Mary Avriette, Adolfo Garcia-Sastre, Gary White, Catherine Woods, Ronald Kennedy, Constantin Bona

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

DNA immunization is a potential vaccination strategy for neonates and infants. We tested the ability of a prototype DNA vaccine against influenza virus to prime lasting immunity when administered to newborn non-human primates. Neonatal DNA vaccination triggered virus-specific and neutralizing antibodies of titers and persistence depending on the vaccine dose. Subsequent exposure to influenza virus, revealed significantly increased recall responses in the baboons vaccinated with DNA during the neonatal stage. The humoral and cellular responses were enhanced in the baboons primed with DNA vaccine as neonates. Thus, neonatal DNA vaccination of non-human primates triggered immune memory that persisted beyond infancy.

Original languageEnglish
Pages (from-to)1960-1967
Number of pages8
JournalVaccine
Volume19
Issue number15-16
DOIs
StatePublished - 28 Feb 2001

Keywords

  • DNA vaccination
  • Influenza virus
  • Neonates
  • Primates

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