@article{de475d352361422aa38dbe595aab842d,
title = "Induction of developmental hematopoiesis mediated by transcription factors and the hematopoietic microenvironment",
abstract = "The induction of hematopoiesis in various cell types via transcription factor (TF) reprogramming has been demonstrated by several strategies. The eventual goal of these approaches is to generate a product for unmet needs in hematopoietic cell transplantation therapies. The most successful strategies hew closely to clues provided from developmental hematopoiesis in terms of factor expression and environmental cues. In this review, we aim to summarize the TFs that play important roles in developmental hematopoiesis primarily and to also touch on adult hematopoiesis. Several aspects of cellular and molecular biology coalesce in this process, with TFs and surrounding cellular signals playing a major role in the overall development of the hematopoietic lineage. We attempt to put these elements into the context of reprogramming and highlight their roles.",
keywords = "hematopoiesis, hematopoietic microenvironment, reprogramming, stroma, transcription factors",
author = "Daniel, {Michael G.} and Katrina Rapp and Christoph Schaniel and Moore, {Kateri A.}",
note = "Funding Information: The authors would like to thank Sunita L. D'Souza and the Pluripotent Stem Cell Core at the Icahn School of Medicine at Mount Sinai for helpful discussions. We also thank the Flow Cytometry Shared Resource Core and the Genomics Core Facility at the Icahn School of Medicine at Mount Sinai. K.A.M. was supported by NIH 5RO1HL119404 and NYSTEM C32597GG, and M.G.D. was supported by NIH Grants 5RO1HL11904, 4R33AI116191-031, and F31 HL136148-01. Funding Information: The authors would like to thank Sunita L. D{\textquoteright}Souza and the Pluripotent Stem Cell Core at the Icahn School of Medicine at Mount Sinai for helpful discussions. We also thank the Flow Cytometry Shared Resource Core and the Genomics Core Facility at the Icahn School of Medicine at Mount Sinai. K.A.M. was supported by NIH 5RO1HL119404 and NYSTEM C32597GG, and M.G.D. was supported by NIH Grants 5RO1HL11904, 4R33AI116191-031, and F31 HL136148-01. Publisher Copyright: {\textcopyright} 2019 New York Academy of Sciences.",
year = "2020",
doi = "10.1111/nyas.14246",
language = "English",
volume = "1466",
pages = "59--72",
journal = "Annals of The Lyceum of Natural History of New York",
issn = "0890-6564",
publisher = "New York Academy of Sciences",
number = "1",
}