Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant newcastle disease virus expressing a north american lineage H7 subtype hemagglutinin

Peter H. Goff, Florian Krammer, Rong Hai, Christopher W. Seibert, Irina Margine, Adolfo García-Sastre, Peter Palesea

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Severe human disease caused by the emerging H7N9 influenza virus in China warrants a rapid response. Here, we present a recombinant Newcastle disease virus expressing a North American lineage H7 influenza virus hemagglutinin. Sera from immunized mice were cross-reactive to a broad range of H7 subtype viruses and inhibited hemagglutination by the novel H7 hemagglutinin. Immunized mice were protected against a heterologous H7 subtype challenge, and genetic analysis suggested that cross-protective antibodies recognize conserved antigenic sites.

Original languageEnglish
Pages (from-to)8235-8240
Number of pages6
JournalJournal of Virology
Volume87
Issue number14
DOIs
StatePublished - Jul 2013

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