Abstract
Severe human disease caused by the emerging H7N9 influenza virus in China warrants a rapid response. Here, we present a recombinant Newcastle disease virus expressing a North American lineage H7 influenza virus hemagglutinin. Sera from immunized mice were cross-reactive to a broad range of H7 subtype viruses and inhibited hemagglutination by the novel H7 hemagglutinin. Immunized mice were protected against a heterologous H7 subtype challenge, and genetic analysis suggested that cross-protective antibodies recognize conserved antigenic sites.
Original language | English |
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Pages (from-to) | 8235-8240 |
Number of pages | 6 |
Journal | Journal of Virology |
Volume | 87 |
Issue number | 14 |
DOIs | |
State | Published - Jul 2013 |