INDUCTION OF CHROMOSOME ABERRATIONS IN ICR 2A FROG CELLS EXPOSED TO265–313 nm MONOCHROMATIC ULTRAVIOLET WAVELENGTHS and PHOTOREACTIVATING LIGHT

Barry S. Rosenstein, Rebecca B. Rosenstein

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Abstract— Exposure of ICR 2A cells to either 265, 289, 302 or 313 nm monochromatic UV wavelengths caused the induction of chromosome aberrations with chromatid gaps and breaks being the most common type of aberration detected. Treatment of U V‐irradiated cells with photoreactivating light (PRL) resulted in a lower yield of aberrations demonstrating that pyrimidine dimers are involved in the formation of chromosome aberrations induced by the UV wavelengths tested. However, the decrease in the level of aberrations resulting from PRL treatment of 313 nm‐irradiated cells was significantly less than for the other wavelengths indicating that non‐dimer photoproducts may have played an important additional role in the induction of chromosome aberrations by this UV wavelength.

Original languageEnglish
Pages (from-to)57-61
Number of pages5
JournalPhotochemistry and Photobiology
Volume41
Issue number1
DOIs
StatePublished - Jan 1985
Externally publishedYes

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