Induction of behavioral supersensitivity to apomorphine by DFP treatment

Kenneth L. Davis, Gordon S. Rosenberg

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The effect of DFP, a long-acting inhibitor of acetylcholinsterase, on apomorphine-induced climbing behavior, was tested in mice. Twelve hours following the intraperitoneal administration of a single dose of DFP, animals demonstrated a significant increase in apomorphine-induced climbing behavior. This effect was not observed twenty-four hours following DFP pretreatment. These results suggest that acute administration of a cholinomimetic agent, may produce behavioral supersensitivity to dopamine agonists.

Original languageEnglish
Pages (from-to)1953-1959
Number of pages7
JournalLife Sciences
Volume28
Issue number17
DOIs
StatePublished - 27 Apr 1981
Externally publishedYes

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