Induced proximity for dephosphorylation

Kwang Su Park; Taeg Kyu Kwon

doi:10.1016/j.tips.2026.02.010

Induced proximity for dephosphorylation

Kwang Su Park
, Taeg Kyu Kwon

Research output: Contribution to journal › Short survey › peer-review

Abstract

Induced-proximity dephosphorylation is a strategy that recruits phosphatases to target proteins for selective and reversible phosphate removal. This strategy enables context-dependent reprogramming of pathological phosphorylation with improved mechanistic and pathway specificity. In this forum article, we outline its mechanistic basis, summarize recent advances, and discuss emerging therapeutic implications.

Original language	English
Pages (from-to)	470-473
Number of pages	4
Journal	Trends in Pharmacological Sciences
Volume	47
Issue number	5
DOIs	https://doi.org/10.1016/j.tips.2026.02.010
State	Published - May 2026
Externally published	Yes

Keywords

dephosphorylation
induced proximity
phosphatase recruitment
phosphorylation modulation

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10.1016/j.tips.2026.02.010

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title = "Induced proximity for dephosphorylation",

abstract = "Induced-proximity dephosphorylation is a strategy that recruits phosphatases to target proteins for selective and reversible phosphate removal. This strategy enables context-dependent reprogramming of pathological phosphorylation with improved mechanistic and pathway specificity. In this forum article, we outline its mechanistic basis, summarize recent advances, and discuss emerging therapeutic implications.",

keywords = "dephosphorylation, induced proximity, phosphatase recruitment, phosphorylation modulation",

author = "Park, \{Kwang Su\} and Kwon, \{Taeg Kyu\}",

note = "Publisher Copyright: {\textcopyright} 2026 Elsevier Ltd",

year = "2026",

month = may,

doi = "10.1016/j.tips.2026.02.010",

language = "English",

volume = "47",

pages = "470--473",

journal = "Trends in Pharmacological Sciences",

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TY - JOUR

T1 - Induced proximity for dephosphorylation

AU - Park, Kwang Su

AU - Kwon, Taeg Kyu

PY - 2026/5

Y1 - 2026/5

N2 - Induced-proximity dephosphorylation is a strategy that recruits phosphatases to target proteins for selective and reversible phosphate removal. This strategy enables context-dependent reprogramming of pathological phosphorylation with improved mechanistic and pathway specificity. In this forum article, we outline its mechanistic basis, summarize recent advances, and discuss emerging therapeutic implications.

AB - Induced-proximity dephosphorylation is a strategy that recruits phosphatases to target proteins for selective and reversible phosphate removal. This strategy enables context-dependent reprogramming of pathological phosphorylation with improved mechanistic and pathway specificity. In this forum article, we outline its mechanistic basis, summarize recent advances, and discuss emerging therapeutic implications.

KW - dephosphorylation

KW - induced proximity

KW - phosphatase recruitment

KW - phosphorylation modulation

UR - https://www.scopus.com/pages/publications/105033762539

U2 - 10.1016/j.tips.2026.02.010

DO - 10.1016/j.tips.2026.02.010

M3 - Short survey

AN - SCOPUS:105033762539

SN - 0165-6147

VL - 47

SP - 470

EP - 473

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 5

ER -

Induced proximity for dephosphorylation

Abstract

Keywords

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