Induced pluripotent stem cells (iPSCs) and neurological disease modeling: Progress and promises

Maria C. Marchetto, Kristen J. Brennand, Leah F. Boyer, Fred H. Gage

Research output: Contribution to journalArticlepeer-review

152 Scopus citations

Abstract

The systematic generation of neurons from patients with neurological disorders can provide important insights into disease pathology, progression and mechanism. This review will discuss recent progress in modeling neurodegenerative and neurodevelopmental diseases using induced pluripotent stem cells (iPSCs) and highlight some of the current challenges in the field. Combined with other technologies previously used to study brain disease, iPSC modeling has the promise to influence modern medicine on several fronts: early diagnosis, drug development and effective treatment.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalHuman Molecular Genetics
Volume20
Issue numberR2
DOIs
StatePublished - 15 Oct 2011
Externally publishedYes

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