Induced neuronal cells: How to make and define a neuron

Nan Yang; Yi Han Ng; Zhiping P. Pang; Thomas C. Südhof; Marius Wernig

doi:10.1016/j.stem.2011.11.015

Induced neuronal cells: How to make and define a neuron

Nan Yang
, Yi Han Ng
, Zhiping P. Pang
, Thomas C. Südhof
, Marius Wernig

Research output: Contribution to journal › Review article › peer-review

158 Scopus citations

Abstract

Cellular plasticity is a major focus of investigation in developmental biology. The recent discovery that induced neuronal (iN) cells can be generated from mouse and human fibroblasts by expression of defined transcription factors suggested that cell fate plasticity is much wider than previously anticipated. In this review, we summarize the most recent developments in this nascent field and suggest criteria to help define and categorize iN cells that take into account the complexity of neuronal identity.

Original language	English
Pages (from-to)	517-525
Number of pages	9
Journal	Cell Stem Cell
Volume	9
Issue number	6
DOIs	https://doi.org/10.1016/j.stem.2011.11.015
State	Published - 2 Dec 2011
Externally published	Yes

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10.1016/j.stem.2011.11.015

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title = "Induced neuronal cells: How to make and define a neuron",

abstract = "Cellular plasticity is a major focus of investigation in developmental biology. The recent discovery that induced neuronal (iN) cells can be generated from mouse and human fibroblasts by expression of defined transcription factors suggested that cell fate plasticity is much wider than previously anticipated. In this review, we summarize the most recent developments in this nascent field and suggest criteria to help define and categorize iN cells that take into account the complexity of neuronal identity.",

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AU - Yang, Nan

AU - Ng, Yi Han

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AU - Südhof, Thomas C.

AU - Wernig, Marius

PY - 2011/12/2

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AB - Cellular plasticity is a major focus of investigation in developmental biology. The recent discovery that induced neuronal (iN) cells can be generated from mouse and human fibroblasts by expression of defined transcription factors suggested that cell fate plasticity is much wider than previously anticipated. In this review, we summarize the most recent developments in this nascent field and suggest criteria to help define and categorize iN cells that take into account the complexity of neuronal identity.

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DO - 10.1016/j.stem.2011.11.015

M3 - Review article

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JO - Cell Stem Cell

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Induced neuronal cells: How to make and define a neuron

Abstract

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