Indocyanine green angiography: A clinical comparison of scanning L VSER ophthalmoscope to fundus camera-based videodigital technology

Purpose. To compare the clinical utility of the two existing indocyanme green angiography (ICGA) systems in detecting choroidal neovasculanzation (CNV) from age-related macular degeneration (AMD>. Methods. The Angioscan confocal scanning laser ophthalmoscope (SLO) an J the Topcon Imagenet high-resoluiion fundus camera-based systems were placed side-by-side. In a prospective, consecutive fashion, eyes with acute, exudative AMD were imaged with both systems simultaneously. Images obtained at three, pre-determined time intervals (<2, 6 to 10, and > 18 minutes) were then compared with respect to CNV delineation by two observers, one of whom was unaware of the purpose of the study. Results. Eleven eyes of 10 patit nts were studied. In, 9 of 11 (82%) eyes, the two systems showed a high degree of concordance with respect to CNV location, size, and configuration during ail three time intervals. However, in 4 of these 9 eyes, vascular detail was judged t y the masked observer to be qualitatively better in the early phase (<2 minutes) with the SLO system. In 2 of 11 ( 18%) eyes, a larger area of abnormal plaque-like hyperfluorescence was seen in the late phase (>18 minutes) only with the fundus carrera system. Conclusions. In general, the two technologies have a similar overa 1 diagnostic yield in delineating AMDrelated CNV. There was a strong tendency for there to be better earlier CNV detail with the SLO-based system and occasion il, better plaque-like fluorescence detail m the late phases with the fundus camera-bised system.