Indium triflate catalyzed one-pot multicomponent synthesis of spiro-hexahydropyrimidines explained by multiple covalent bond formation

Anshu Dandia, Anuj K. Jain, Sonam Sharma

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

A mild, efficient, and expeditious method has been developed for the synthesis of spiro-hexahydropyrimidine derivatives via a three-component, one-pot cyclocondensation reaction of aromatic amines, formaldehyde, and cyclic ketones in 4-6 h using In(OTf) 3 as Lewis acid catalyst for the first time. The reaction involving creation of six new covalent bonds was efficiently promoted by 10 mol % In(OTf) 3 and the catalyst could be recovered easily after the reaction and reused without any loss of its catalytic activity. The advantageous features of this methodology are high atom-economy, operational simplicity, shorter reaction time, and easy handling.

Original languageEnglish
Pages (from-to)5270-5274
Number of pages5
JournalTetrahedron Letters
Volume53
Issue number39
DOIs
StatePublished - 26 Sep 2012
Externally publishedYes

Keywords

  • Indium triflate
  • Multicomponent reaction
  • Spiro-hexahydropyrimidines

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