Indium-111-labeled leukocyte scintigraphy in hemodialysis access-site infection

C. J. Palestro, A. Vega, C. K. Kim, S. Vallabhajosula, S. J. Goldsmith

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32 Scopus citations

Abstract

Bacterial sepsis, a significant complication of chronic hemodialysis, is generally the result of infection at the vascular access site. We retrospectively reviewed the utility of indium-111-(111In) labeled autologous leukocyte scintigraphy in 26 patients (30 scans) with synthetic vascular grafts, on chronic hemodialysis, in whom hemodialysis access site infection was a diagnostic consideration. Leukocyte scintigraphy correctly identified all fifteen access-site infections; there was one false-positive study, for an overall sensitivity and specificity of 100% and 93%, respectively. Of particular significance is the fact that in nine (60%) of the fifteen access-site infections, physical examination was normal. Our data indicate that 111In-labeled leukocyte scintigraphy is a useful procedure for the diagnosis of hemodialysis access-site infection, and it is especially valuable when physical examination of the access site is normal.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalJournal of Nuclear Medicine
Volume31
Issue number3
StatePublished - 1990

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