Indirect comparison meta-analysis of aspirin therapy after coronary surgery

Eric Lim, Ziad Ali, Ayyaz Ali, Tom Routledge, Lyn Edmonds, Douglas G. Altman, Stephen Large

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Objectives: To evaluate the efficacy of low and medium dose aspirin therapy after coronary surgery by using an indirect comparison meta-analysis. Data sources: Systematic literature search of Medline, Embase, Cochrane controlled trials register, and trial register sites on the internet. Study selection: Outcome was evaluated by angiography and reported as graft occlusion and rate of events in patients. Trials that did not include aspirin as the sole therapy or did not have a placebo control arm were excluded. Articles were assessed for eligibility and quality and grouped according to dosage. The estimated difference in effect of low and medium dose aspirin on graft occlusion was obtained by combining the estimated log relative risks of low dose with placebo and medium dose with placebo. Results: For graft occlusion, the medium dose trials yielded a relative risk reduction of 45% compared with 26% for the low dose trials. The greater effect in the medium dose trials is summarised by a relative risk ratio of 0.74 (95% confidence interval 0.52 to 1.06; P = 0.10) for graft occlusion and 0.81 (0.57 to 1.16; P = 0.25) for events in patients. Conclusions: Medium dose aspirin may more successfully reduce graft occlusion than low dose regimens within the first year after coronary surgery.

Original languageEnglish
Pages (from-to)1309-1311
Number of pages3
JournalThe BMJ
Issue number7427
StatePublished - 6 Dec 2003
Externally publishedYes


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