@article{967cb22b49684451a50db26063860dc7,
title = "Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunization",
abstract = "The main barrier to reduction of morbidity caused by influenza is the absence of a vaccine that elicits broad protection against different virus strains. Studies in preclinical models of influenza virus infections have shown that antibodies alone are sufficient to provide broad protection against divergent virus strains in vivo. Here, we address the challenge of identifying an immunogen that can elicit potent, broadly protective, antiinfluenza antibodies by demonstrating that immune complexes composed of sialylated antihemagglutinin antibodies and seasonal inactivated flu vaccine (TIV) can elicit broadly protective antihemagglutinin antibodies. Further, we found that an Fc-modified, bispecific monoclonal antibody against conserved epitopes of the hemagglutinin can be combined with TIV to elicit broad protection, thus setting the stage for a universal influenza virus vaccine.",
keywords = "CD23, Immune complex, Sialylated Fc, TIV, Universal influenza vaccine",
author = "Jad Maamary and Wang, {Taia T.} and Tan, {Gene S.} and Peter Palese and Ravetch, {Jeffrey V.}",
note = "Funding Information: ACKNOWLEDGMENTS. We thank Florian Krammer (Icahn School of Medicine, New York, NY) for providing HA proteins and Daniel H. Conrad (Virginia Commonwealth University, Richmond, VA) for providing Cd23−/− mice. T.T.W. thanks the Rockefeller University, Rockefeller University Hospital, and Rockefeller University KL2 Clinical Scholars Program for training and support. Research reported in this publication was supported by the NIAID of the National Institutes of Health (NIH) under Awards U19AI111825 (to J.V.R.), NIH 5U19AI109946 (to J.V.R. and P.P.), and HHSN272201400008C (to P.P.). T.T.W. was supported, in part, by the Chan Zuckerberg Biohub, Stanford University School of Medicine; Grant UL1 TR001866 from the National Center for Advancing Translational Sciences (NCATS); NIH Clinical and Translational Science Award (CTSA) program; and by NIAID K22 Grant 1 K22 AI123478-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The data presented in this manuscript are tabulated in the main paper and in Figs. S1 and S2. Publisher Copyright: {\textcopyright} 2017, National Academy of Sciences. All rights reserved.",
year = "2017",
month = sep,
day = "19",
doi = "10.1073/pnas.1707950114",
language = "English",
volume = "114",
pages = "10172--10177",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "38",
}