Increasing public trust and confidence in psychiatric research

D. S. Charney; R. B. Innis; E. J. Nestler; K. L. Davis; C. B. Nemeroff; D. R. Weinberger

doi:10.1016/S0006-3223(99)00096-7

Increasing public trust and confidence in psychiatric research

D. S. Charney, R. B. Innis, E. J. Nestler, K. L. Davis, C. B. Nemeroff, D. R. Weinberger

Research output: Contribution to journal › Editorial

2 Scopus citations

Original language	English
Pages (from-to)	1-2
Number of pages	2
Journal	Biological Psychiatry
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/S0006-3223(99)00096-7
State	Published - 1999
Externally published	Yes

Access to Document

10.1016/S0006-3223(99)00096-7

Cite this

@article{d4c3dea916e3428d87488d07a1820ce4,

title = "Increasing public trust and confidence in psychiatric research",

author = "Charney, {D. S.} and Innis, {R. B.} and Nestler, {E. J.} and Davis, {K. L.} and Nemeroff, {C. B.} and Weinberger, {D. R.}",

note = "Funding Information: The National Advisory Mental Health Council of the NIMH has recently established a Human Subjects Research Workgroup to review grant applications that are under active consideration for funding and entail a clinically significant period of treatment discontinuation or delay, or symptom provocation procedures. This Workgroup will evaluate the scientific merit of these applications and the adequacy of consent documents and proposed safeguards. Based on its review, the Workgroup will advise the Council whether to recommend concurrence with the peer review group approval, non-concurrence, or deferral for additional information. We support these new procedures. Investigation of the neurobiological basis of neuropsychiatric disorders is among the most daunting of endeavors, given the relative inaccessibility of the brain for research purposes. It is in this context that research strategies involving symptom provocation and therapeutic drug discontinuation or treatment delay have emerged. It is clear that such studies should only focus on the most important scientific questions using state of the art research design. The risk-benefit assessment of this type of research is difficult and requires the input of many interested parties, including patients, family members, advocates, and researchers. The NIMH action may help restore the confidence of our patients and advocates that we take these issues very seriously. Of course, similar procedures should also be in place at the local level.",

year = "1999",

doi = "10.1016/S0006-3223(99)00096-7",

language = "English",

volume = "46",

pages = "1--2",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier USA",

number = "1",

}

TY - JOUR

T1 - Increasing public trust and confidence in psychiatric research

AU - Charney, D. S.

AU - Innis, R. B.

AU - Nestler, E. J.

AU - Davis, K. L.

AU - Nemeroff, C. B.

AU - Weinberger, D. R.

N1 - Funding Information: The National Advisory Mental Health Council of the NIMH has recently established a Human Subjects Research Workgroup to review grant applications that are under active consideration for funding and entail a clinically significant period of treatment discontinuation or delay, or symptom provocation procedures. This Workgroup will evaluate the scientific merit of these applications and the adequacy of consent documents and proposed safeguards. Based on its review, the Workgroup will advise the Council whether to recommend concurrence with the peer review group approval, non-concurrence, or deferral for additional information. We support these new procedures. Investigation of the neurobiological basis of neuropsychiatric disorders is among the most daunting of endeavors, given the relative inaccessibility of the brain for research purposes. It is in this context that research strategies involving symptom provocation and therapeutic drug discontinuation or treatment delay have emerged. It is clear that such studies should only focus on the most important scientific questions using state of the art research design. The risk-benefit assessment of this type of research is difficult and requires the input of many interested parties, including patients, family members, advocates, and researchers. The NIMH action may help restore the confidence of our patients and advocates that we take these issues very seriously. Of course, similar procedures should also be in place at the local level.

PY - 1999

Y1 - 1999

UR - http://www.scopus.com/inward/record.url?scp=0032987266&partnerID=8YFLogxK

U2 - 10.1016/S0006-3223(99)00096-7

DO - 10.1016/S0006-3223(99)00096-7

M3 - Editorial

C2 - 10394467

AN - SCOPUS:0032987266

SN - 0006-3223

VL - 46

SP - 1

EP - 2

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 1

ER -