Increasing evidence for the use of sodium oxybate in multi-drug-resistant lance–adams syndrome

Giulietta M. Riboldi; Steven J. Frucht

doi:10.5334/tohm.472

Increasing evidence for the use of sodium oxybate in multi-drug-resistant lance–adams syndrome

Giulietta M. Riboldi, Steven J. Frucht

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3 Scopus citations

Abstract

Background: Treatment of posthypoxic myoclonus (PHM) can be a challenge in patients not responsive to first-line medications. PMH is a rare condition that has a dramatic impact on patients’ quality of life. Refractory cases are not uncommon. Case report: We report a patient with PHM non-responsive to conventional treatments who showed a dramatic improvement with sodium oxybate (SBX). Cases of PHM treated with SBX reported in the literature were reviewed. Discussion: Resting and stimulus-induced myoclonus respond robustly to SBX, with significant improvement in patients’ quality of life. SBX may be considered in patients with PHM resistant to first-line medications.

Original language	English
Journal	Tremor and Other Hyperkinetic Movements
Volume	9
DOIs	https://doi.org/10.5334/tohm.472
State	Published - 2019
Externally published	Yes

Keywords

Lance–Adams syndrome
Posthypoxic myoclonus
alcohol-sensitive myoclonus
refractory myoclonus
sodium oxybate

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10.5334/tohm.472

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title = "Increasing evidence for the use of sodium oxybate in multi-drug-resistant lance–adams syndrome",

abstract = "Background: Treatment of posthypoxic myoclonus (PHM) can be a challenge in patients not responsive to first-line medications. PMH is a rare condition that has a dramatic impact on patients{\textquoteright} quality of life. Refractory cases are not uncommon. Case report: We report a patient with PHM non-responsive to conventional treatments who showed a dramatic improvement with sodium oxybate (SBX). Cases of PHM treated with SBX reported in the literature were reviewed. Discussion: Resting and stimulus-induced myoclonus respond robustly to SBX, with significant improvement in patients{\textquoteright} quality of life. SBX may be considered in patients with PHM resistant to first-line medications.",

keywords = "Lance–Adams syndrome, Posthypoxic myoclonus, alcohol-sensitive myoclonus, refractory myoclonus, sodium oxybate",

author = "Riboldi, {Giulietta M.} and Frucht, {Steven J.}",

year = "2019",

doi = "10.5334/tohm.472",

language = "English",

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journal = "Tremor and Other Hyperkinetic Movements",

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T1 - Increasing evidence for the use of sodium oxybate in multi-drug-resistant lance–adams syndrome

AU - Riboldi, Giulietta M.

AU - Frucht, Steven J.

PY - 2019

Y1 - 2019

N2 - Background: Treatment of posthypoxic myoclonus (PHM) can be a challenge in patients not responsive to first-line medications. PMH is a rare condition that has a dramatic impact on patients’ quality of life. Refractory cases are not uncommon. Case report: We report a patient with PHM non-responsive to conventional treatments who showed a dramatic improvement with sodium oxybate (SBX). Cases of PHM treated with SBX reported in the literature were reviewed. Discussion: Resting and stimulus-induced myoclonus respond robustly to SBX, with significant improvement in patients’ quality of life. SBX may be considered in patients with PHM resistant to first-line medications.

AB - Background: Treatment of posthypoxic myoclonus (PHM) can be a challenge in patients not responsive to first-line medications. PMH is a rare condition that has a dramatic impact on patients’ quality of life. Refractory cases are not uncommon. Case report: We report a patient with PHM non-responsive to conventional treatments who showed a dramatic improvement with sodium oxybate (SBX). Cases of PHM treated with SBX reported in the literature were reviewed. Discussion: Resting and stimulus-induced myoclonus respond robustly to SBX, with significant improvement in patients’ quality of life. SBX may be considered in patients with PHM resistant to first-line medications.

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KW - Posthypoxic myoclonus

KW - alcohol-sensitive myoclonus

KW - refractory myoclonus

KW - sodium oxybate

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JO - Tremor and Other Hyperkinetic Movements

JF - Tremor and Other Hyperkinetic Movements

ER -

Increasing evidence for the use of sodium oxybate in multi-drug-resistant lance–adams syndrome

Abstract

Keywords

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