Increasing Evidence for the Use of Sodium Oxybate in Multi-Drug-Resistant Lance-Adams Syndrome

Giulietta M. Riboldi, Steven J. Frucht

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Treatment of posthypoxic myoclonus (PHM) can be a challenge in patients not responsive to first-line medications. PMH is a rare condition that has a dramatic impact on patients' quality of life. Refractory cases are not uncommon. Case report: We report a patient with PHM non-responsive to conventional treatments who showed a dramatic improvement with sodium oxybate (SBX). Cases of PHM treated with SBX reported in the literature were reviewed. Discussion: Resting and stimulus-induced myoclonus respond robustly to SBX, with significant improvement in patients' quality of life. SBX may be considered in patients with PHM resistant to first-line medications.

Original languageEnglish
JournalTremor and Other Hyperkinetic Movements
Volume9
DOIs
StatePublished - 2019
Externally publishedYes

Keywords

  • Lance–Adams syndrome
  • Posthypoxic myoclonus
  • alcohol-sensitive myoclonus
  • refractory myoclonus
  • sodium oxybate

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