TY - JOUR
T1 - Increasing evidence for the use of sodium oxybate in multi-drug-resistant lance–adams syndrome
AU - Riboldi, Giulietta M.
AU - Frucht, Steven J.
N1 - Publisher Copyright:
© 2019 Riboldi and Frucht. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Background: Treatment of posthypoxic myoclonus (PHM) can be a challenge in patients not responsive to first-line medications. PMH is a rare condition that has a dramatic impact on patients’ quality of life. Refractory cases are not uncommon. Case report: We report a patient with PHM non-responsive to conventional treatments who showed a dramatic improvement with sodium oxybate (SBX). Cases of PHM treated with SBX reported in the literature were reviewed. Discussion: Resting and stimulus-induced myoclonus respond robustly to SBX, with significant improvement in patients’ quality of life. SBX may be considered in patients with PHM resistant to first-line medications.
AB - Background: Treatment of posthypoxic myoclonus (PHM) can be a challenge in patients not responsive to first-line medications. PMH is a rare condition that has a dramatic impact on patients’ quality of life. Refractory cases are not uncommon. Case report: We report a patient with PHM non-responsive to conventional treatments who showed a dramatic improvement with sodium oxybate (SBX). Cases of PHM treated with SBX reported in the literature were reviewed. Discussion: Resting and stimulus-induced myoclonus respond robustly to SBX, with significant improvement in patients’ quality of life. SBX may be considered in patients with PHM resistant to first-line medications.
KW - Lance–Adams syndrome
KW - Posthypoxic myoclonus
KW - alcohol-sensitive myoclonus
KW - refractory myoclonus
KW - sodium oxybate
UR - http://www.scopus.com/inward/record.url?scp=85069848466&partnerID=8YFLogxK
U2 - 10.7916/d8-rnsh-c024
DO - 10.7916/d8-rnsh-c024
M3 - Article
C2 - 31413889
AN - SCOPUS:85069848466
SN - 2160-8288
VL - 9
JO - Tremor and Other Hyperkinetic Movements
JF - Tremor and Other Hyperkinetic Movements
ER -