Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder

Patrick M. Brunner, Jonathan I. Silverberg, Emma Guttman-Yassky, Amy S. Paller, Kenji Kabashima, Masayuki Amagai, Thomas A. Luger, Mette Deleuran, Thomas Werfel, Kilian Eyerich, Georg Stingl, Martine Bagot, Dirk Jan Hijnen, Michael Ardern-Jones, Nick Reynolds, Phyllis Spuls, Alain Taieb

Research output: Contribution to journalShort surveypeer-review

285 Scopus citations


Atopic dermatitis comorbidities extend well beyond the march to allergic conditions (food allergy, asthma, allergic rhinitis, allergic conjunctivitis, and eosinophilic esophagitis), suggesting both cutaneous and systemic immune activation. In reviewing atopic dermatitis comorbidities, Councilors of the International Eczema Council found a strong pattern of immune activation in peripheral blood and the propensity to both skin and systemic infections. Associations with cardiovascular, neuropsychiatric, and malignant diseases were increasingly reported, but confirmation of their link with atopic dermatitis requires longitudinal studies. Given the possibility of atopic dermatitis-related systemic immune activation, future investigations of new interventions should concurrently examine the impact on these comorbidities.

Original languageEnglish
Pages (from-to)18-25
Number of pages8
JournalJournal of Investigative Dermatology
Issue number1
StatePublished - 1 Jan 2017


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