TY - JOUR
T1 - Increased Visceral Adipose Tissue Without Weight Retention at 59 Weeks Postpartum
AU - Janumala, Isaiah
AU - Toro-Ramos, Tatiana
AU - Widen, Elizabeth
AU - Rosenn, Barak
AU - Crane, Janet
AU - Horowitz, Michelle
AU - Lin, Susan
AU - Gidwani, Sonia
AU - Paley, Charles
AU - Thornton, John C.
AU - Pi-Sunyer, F. Xavier
AU - Gallagher, Dympna
N1 - Funding Information:
We thank LIFE-Moms consortium members for their contributions to the development and oversight of common measures and procedures across the trials; LIFT women and infants for enrolling in this study; LIFT staff for their herculean efforts (Kasey Faulkner, Maryanne Holowaty, Jill Johnson, Kim Kelly, Rachel Koletsky, Jennifer Patricio, Julie Roman, and Wen Yu); and Rebecca Gersnoviez Clifton at The George Washington University Biostatistics Center for guidance specific to LIFE-Moms consortium outcomes and definitions. All data generated from this study will be administered in accordance with University and NIH policies, including the most current NIH data release and resource sharing policy. The results from this work will be presented at scientific meetings, published in scientific journals, and made freely available to the public according to NIH guidelines.
Funding Information:
This work was supported by NIH grants U01‐DK094463, U01‐DK094463‐Supplement (Supplement to promote diversity, TTR), P30‐DK026687, T32‐DK007559 (TTR, EW), T32DK091227 (EW), and K99/R00HD086304 (EW).
Funding Information:
Research reported in this publication was also supported by NIH through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, U01 DK094418, U01 DK094416, 5U01 DK094466 [RCU]), the National Heart, Lung, and Blood Institute (U01 HL114344, U01 HL114377), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (U01 HD072834), the National Center for Complementary and Integrative Health, the NIH Office of Research in Women's Health, the Office of Behavioral and Social Science Research, the NIH Office of Disease Prevention, the Indian Health Service, the Intramural Research Program of the NIDDK, and the Office of the Director, NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2020 The Obesity Society.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Objective: This study aimed to determine whether controlling maternal gestational weight gain (GWG) influences adipose tissue distribution at 1 year postpartum. Methods: Women with overweight or obesity (n = 210, BMI ≥ 25 or ≥ 30) were randomized to a lifestyle intervention (LI) designed to control GWG or to usual obstetrical care (UC). Measures included anthropometry, whole-body magnetic resonance imaging for visceral (VAT), intermuscular, and subcutaneous adipose tissue, and cardiometabolic risk factors in pregnancy (15 and 35 weeks) and after delivery (15 and 59 weeks). Results: Baseline (15 weeks) characteristics were similar (mean [SD]: age, 33.8 [4.3] years; weight, 81.9 [13.7] kg; BMI, 30.4 [4.5]; gestational age at randomization, 14.9 [0.8] weeks). LI had less GWG (1.79 kg; P = 0.003) and subcutaneous adipose tissue gain at 35 weeks gestation (P < 0.01). UC postpartum weight (2.92 kg) was higher at 15 weeks but not different from baseline or LI at 59 weeks postpartum. Postpartum VAT increased from baseline in LI by 0.23 kg at 15 weeks and 0.55 kg at 59 weeks; in UC, it increased by 0.34 kg at 15 and 59 weeks. Intermuscular adipose tissue remained elevated in LI (0.22 kg) at 59 weeks. VAT was associated with several cardiometabolic risk factors at 59 weeks. Conclusions: Despite no weight retention at 59 weeks postpartum, women had increased VAT by ~30%. Postpartum modifiable behaviors are warranted to lower the risk of VAT retention.
AB - Objective: This study aimed to determine whether controlling maternal gestational weight gain (GWG) influences adipose tissue distribution at 1 year postpartum. Methods: Women with overweight or obesity (n = 210, BMI ≥ 25 or ≥ 30) were randomized to a lifestyle intervention (LI) designed to control GWG or to usual obstetrical care (UC). Measures included anthropometry, whole-body magnetic resonance imaging for visceral (VAT), intermuscular, and subcutaneous adipose tissue, and cardiometabolic risk factors in pregnancy (15 and 35 weeks) and after delivery (15 and 59 weeks). Results: Baseline (15 weeks) characteristics were similar (mean [SD]: age, 33.8 [4.3] years; weight, 81.9 [13.7] kg; BMI, 30.4 [4.5]; gestational age at randomization, 14.9 [0.8] weeks). LI had less GWG (1.79 kg; P = 0.003) and subcutaneous adipose tissue gain at 35 weeks gestation (P < 0.01). UC postpartum weight (2.92 kg) was higher at 15 weeks but not different from baseline or LI at 59 weeks postpartum. Postpartum VAT increased from baseline in LI by 0.23 kg at 15 weeks and 0.55 kg at 59 weeks; in UC, it increased by 0.34 kg at 15 and 59 weeks. Intermuscular adipose tissue remained elevated in LI (0.22 kg) at 59 weeks. VAT was associated with several cardiometabolic risk factors at 59 weeks. Conclusions: Despite no weight retention at 59 weeks postpartum, women had increased VAT by ~30%. Postpartum modifiable behaviors are warranted to lower the risk of VAT retention.
UR - http://www.scopus.com/inward/record.url?scp=85079160269&partnerID=8YFLogxK
U2 - 10.1002/oby.22736
DO - 10.1002/oby.22736
M3 - Article
C2 - 32030911
AN - SCOPUS:85079160269
VL - 28
SP - 552
EP - 562
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 3
ER -