Increased seizure susceptibility in adult rats with neuronal migration disorders

Isabelle M. Germano; Ellen F. Sperber

doi:10.1016/S0006-8993(97)01022-6

Increased seizure susceptibility in adult rats with neuronal migration disorders

Isabelle M. Germano, Ellen F. Sperber

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Recent data show that neuronal migration disorders (NMD) lower the seizure threshold in the immature brain. To assess if this is an age-related phenomenon, kainic acid (KA) was administered to induce status epilepticus in adult rats with NMD. Results of the present study demonstrate that adult rats with NMD had a shorter latency to seizures and longer duration of status epilepticus compared to age-related controls. Furthermore, in mrs with NMD seizures were more severe and status epilepticus-induced mortality was worse than in age-matched controls. These data confirm that NMD lower the seizure threshold in the adult rat. The results of the present study combined with our previous studies in the immature rat, suggest that the facilitating effects of NMD on seizures are not age dependent.

Original language	English
Pages (from-to)	219-222
Number of pages	4
Journal	Brain Research
Volume	777
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(97)01022-6
State	Published - 28 Nov 1997

Keywords

Immunohistochemistry
Kainic acid
Neuronal migration disorder
Status epilepticus

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10.1016/S0006-8993(97)01022-6

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title = "Increased seizure susceptibility in adult rats with neuronal migration disorders",

abstract = "Recent data show that neuronal migration disorders (NMD) lower the seizure threshold in the immature brain. To assess if this is an age-related phenomenon, kainic acid (KA) was administered to induce status epilepticus in adult rats with NMD. Results of the present study demonstrate that adult rats with NMD had a shorter latency to seizures and longer duration of status epilepticus compared to age-related controls. Furthermore, in mrs with NMD seizures were more severe and status epilepticus-induced mortality was worse than in age-matched controls. These data confirm that NMD lower the seizure threshold in the adult rat. The results of the present study combined with our previous studies in the immature rat, suggest that the facilitating effects of NMD on seizures are not age dependent.",

keywords = "Immunohistochemistry, Kainic acid, Neuronal migration disorder, Status epilepticus",

author = "Germano, {Isabelle M.} and Sperber, {Ellen F.}",

note = "Funding Information: This project was partially supported by a research grant from the Epilepsy Foundation of America (I.M.G.) and by NINDS Research Grant NS-30387 (E.F.S.). ",

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T1 - Increased seizure susceptibility in adult rats with neuronal migration disorders

AU - Germano, Isabelle M.

AU - Sperber, Ellen F.

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N2 - Recent data show that neuronal migration disorders (NMD) lower the seizure threshold in the immature brain. To assess if this is an age-related phenomenon, kainic acid (KA) was administered to induce status epilepticus in adult rats with NMD. Results of the present study demonstrate that adult rats with NMD had a shorter latency to seizures and longer duration of status epilepticus compared to age-related controls. Furthermore, in mrs with NMD seizures were more severe and status epilepticus-induced mortality was worse than in age-matched controls. These data confirm that NMD lower the seizure threshold in the adult rat. The results of the present study combined with our previous studies in the immature rat, suggest that the facilitating effects of NMD on seizures are not age dependent.

AB - Recent data show that neuronal migration disorders (NMD) lower the seizure threshold in the immature brain. To assess if this is an age-related phenomenon, kainic acid (KA) was administered to induce status epilepticus in adult rats with NMD. Results of the present study demonstrate that adult rats with NMD had a shorter latency to seizures and longer duration of status epilepticus compared to age-related controls. Furthermore, in mrs with NMD seizures were more severe and status epilepticus-induced mortality was worse than in age-matched controls. These data confirm that NMD lower the seizure threshold in the adult rat. The results of the present study combined with our previous studies in the immature rat, suggest that the facilitating effects of NMD on seizures are not age dependent.

KW - Immunohistochemistry

KW - Kainic acid

KW - Neuronal migration disorder

KW - Status epilepticus

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Increased seizure susceptibility in adult rats with neuronal migration disorders

Abstract

Keywords

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