TY - JOUR
T1 - Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy
AU - Zangari, Maurizio
AU - Anaissie, Elias
AU - Barlogie, Bart
AU - Badros, Ashraf
AU - Desikan, Raman
AU - Viju Gopal, A.
AU - Morris, Christopher
AU - Toor, Amir
AU - Siegel, Eric
AU - Fink, Louis
AU - Tricot, Guido
PY - 2001/9/1
Y1 - 2001/9/1
N2 - The occurrence of deep-vein thrombosis (DVT) in patients with newly diagnosed multiple myeloma, who were randomly assigned to receive identical induction chemotherapy with or without thalidomide, are reported in this study. The 2 study arms were comparable with respect to key myeloma prognostic factors and known risk factors for DVT. One hundred patients received induction chemotherapy including 4 cycles of continuous infusion of combinations of dexamethasone, vincristine, doxorubicin, cyclophosphamide, etoposide, and cisplatin, and each patient completed at least one induction cycle. DVT developed in 14 of 50 patients (28%) randomly assigned to receive thalidomide but in only 2 of 50 patients (4%) not given the agent (P = .002). All episodes of DVT occurred during the first 3 cycles of induction. Administration of thalidomide was resumed safely in 75% of patients receiving anticoagulation therapy. Thus, thalidomide given in combination with multiagent chemotherapy and dexamethasone is associated with a significantly increased risk of DVT, which appears to be safely treated with anticoagulation and does not necessarily warrant discontinuation of thalidomide.
AB - The occurrence of deep-vein thrombosis (DVT) in patients with newly diagnosed multiple myeloma, who were randomly assigned to receive identical induction chemotherapy with or without thalidomide, are reported in this study. The 2 study arms were comparable with respect to key myeloma prognostic factors and known risk factors for DVT. One hundred patients received induction chemotherapy including 4 cycles of continuous infusion of combinations of dexamethasone, vincristine, doxorubicin, cyclophosphamide, etoposide, and cisplatin, and each patient completed at least one induction cycle. DVT developed in 14 of 50 patients (28%) randomly assigned to receive thalidomide but in only 2 of 50 patients (4%) not given the agent (P = .002). All episodes of DVT occurred during the first 3 cycles of induction. Administration of thalidomide was resumed safely in 75% of patients receiving anticoagulation therapy. Thus, thalidomide given in combination with multiagent chemotherapy and dexamethasone is associated with a significantly increased risk of DVT, which appears to be safely treated with anticoagulation and does not necessarily warrant discontinuation of thalidomide.
UR - http://www.scopus.com/inward/record.url?scp=0035469858&partnerID=8YFLogxK
U2 - 10.1182/blood.V98.5.1614
DO - 10.1182/blood.V98.5.1614
M3 - Article
C2 - 11520815
AN - SCOPUS:0035469858
SN - 0006-4971
VL - 98
SP - 1614
EP - 1615
JO - Blood
JF - Blood
IS - 5
ER -