Increased platelet aggregation induced by glucagon administration

S. J. Proctor, T. F. Davies, A. Oxley, P. Jones, A. Heath

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The effect of 1 mg of intravenous glucagon on platelet aggregation has been investigated in 12 normal subjects pre-treated with salicylate. All subjects demonstrated the expected inhibition of collagen-induced secondary aggregation but retained the normal adenosine diphosphate (ADP)-induced primary aggregation phase 18 h after the salicylate therapy (600-1,200mg). Subsequent administration of glucagon caused a significant increase in the ADP-induced primary aggregation phase in the 12 subjects. This data indicates that glucagon increases the reactivity of platelets of ADP and may help to explain the common clinical association of raised plasma glucagon, increased platelet aggregation and vascular disease.

Original languageEnglish
Pages (from-to)6-11
Number of pages6
JournalActa Haematologica
Volume64
Issue number1
DOIs
StatePublished - 1980
Externally publishedYes

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