TY - JOUR
T1 - Increased orocecal transit time in patients with nonalcoholic fatty liver disease
AU - Soza, Alejandro
AU - Riquelme, Arnoldo
AU - González, Robinson
AU - Alvarez, Manuel
AU - Pérez-Ayuso, Rosa María
AU - Glasinovic, Juan Carlos
AU - Arrese, Marco
PY - 2005/6
Y1 - 2005/6
N2 - Intestinal bacterial overgrowth (IBO) has been suggested to play a pathogenic role in patients with nonalcoholic fatty liver disease (NAFLD). Delayed intestinal transit may contribute to IBO development. Ten nondiabetic patients with NAFLD and abnormal liver enzymes were recruited. Ten healthy individuals, matched by sex, age, and body mass index, were used as controls. Orocecal transit time (OCTT) was measured by the lactulose breath test. Anti-endotoxin core antibodies (EndoCAb) were determined. The effect of oral norfloxacin (400 mg BID during 2 weeks) on liver enzymes, lactulose breath test, and EndoCAb was also studied. NAFLD patients had higher basal breathed H 2 and prolonged OCTT compared to controls (127 ± 61 vs. 57 ± 23 min, respectively; P = 0.0037). EndoCAb titers were similar in NAFLD patients and controls. Norfloxacin administration had no effect on ALT levels, lactulose breath test, or EndoCAb titers in patients with NAFLD. The present data show evidence of deranged intestinal motility in nondiabetic patients with NAFLD and support the hypothesis that NAFLD could be linked to endotoxin-induced liver damage of intestinal origin.
AB - Intestinal bacterial overgrowth (IBO) has been suggested to play a pathogenic role in patients with nonalcoholic fatty liver disease (NAFLD). Delayed intestinal transit may contribute to IBO development. Ten nondiabetic patients with NAFLD and abnormal liver enzymes were recruited. Ten healthy individuals, matched by sex, age, and body mass index, were used as controls. Orocecal transit time (OCTT) was measured by the lactulose breath test. Anti-endotoxin core antibodies (EndoCAb) were determined. The effect of oral norfloxacin (400 mg BID during 2 weeks) on liver enzymes, lactulose breath test, and EndoCAb was also studied. NAFLD patients had higher basal breathed H 2 and prolonged OCTT compared to controls (127 ± 61 vs. 57 ± 23 min, respectively; P = 0.0037). EndoCAb titers were similar in NAFLD patients and controls. Norfloxacin administration had no effect on ALT levels, lactulose breath test, or EndoCAb titers in patients with NAFLD. The present data show evidence of deranged intestinal motility in nondiabetic patients with NAFLD and support the hypothesis that NAFLD could be linked to endotoxin-induced liver damage of intestinal origin.
KW - Anti-endotoxin antibodies
KW - EndoCAb
KW - Fatty liver
KW - Intestinal bacterial overgrowth
KW - Nonalcoholic fatty liver
KW - Steatohepatitis
UR - http://www.scopus.com/inward/record.url?scp=20844434973&partnerID=8YFLogxK
U2 - 10.1007/s10620-005-2720-8
DO - 10.1007/s10620-005-2720-8
M3 - Article
C2 - 15986870
AN - SCOPUS:20844434973
SN - 0163-2116
VL - 50
SP - 1136
EP - 1140
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 6
ER -