Increased Hepatic Oxygenation following Ethanol Administration in the Baboon

Spencer Shaw, Elliot A. Heller, Howard S. Friedman, Enrique Baraona, Charles S. Lieber

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

The effects of ethanol on hepatic oxygenation were measured by hepatic vein catheterization in the baboon. Chronic alcohol administration resulted in slightly lower oxygen tension in the hepatic vein, but not ischemia, when measured after an overnight fast when alcohol was no longer present in the blood. Intravenous alcohol administration resulted in an increase in hepatic vein oxygen tension regardless of prior exposure to alcohol or the presence of liver disease. The increased oxygen tension after alcohol was associated with a marked increase in hepatic blood flow. These data in conjunction with the observation of progressive liver injury in the alcohol-fed animals support the concept that alcoholic liver injury can develop despite unimpaired hepatic oxygenation.

Original languageEnglish
Pages (from-to)509-513
Number of pages5
JournalExperimental Biology and Medicine
Volume156
Issue number3
DOIs
StatePublished - Dec 1977
Externally publishedYes

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