Increased frequency of EBV-specific effector memory CD8+ T cells correlates with higher viral load in rheumatoid arthritis

Jan D. Lünemann, Oliver Frey, Thorsten Eidner, Michael Baier, Susanne Roberts, Junji Sashihara, Rudolf Volkmer, Jeffrey I. Cohen, Gert Hein, Thomas Kamradt, Christian Münz

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

EBV is a candidate trigger of rheumatoid arthritis (RA). We determined both EBV-specific T cell and B cell responses and cell-associated EBV DNA copies in patients with RA and demographically matched healthy virus carriers. Patients with RA showed increased and broadened IgG responses to lytic and latent EBV-encoded Ags and 7-fold higher levels of EBV copy numbers in circulating blood cells. Additionally, patients with RA exhibited substantial expansions of CD8+ T cells specific for pooled EBV Ags expressed during both B cell transformation and productive viral replication and the frequency of CD8 + T cells specific for these Ags correlated with cellular EBV copy numbers. In contrast, CD4+ T cell responses to EBV and T cell responses to human CMV Ags were unchanged, altogether arguing against a defective control of latent EBV infection in RA. Our data show that the regulation of EBV infection is perturbed in RA and suggest that increased EBV-specific effector T cell and Ab responses are driven by an elevated EBV load in RA.

Original languageEnglish
Pages (from-to)991-1000
Number of pages10
JournalJournal of Immunology
Volume181
Issue number2
DOIs
StatePublished - 15 Jul 2008
Externally publishedYes

Fingerprint

Dive into the research topics of 'Increased frequency of EBV-specific effector memory CD8+ T cells correlates with higher viral load in rheumatoid arthritis'. Together they form a unique fingerprint.

Cite this