Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development

Yu Mei Ding; Ji Hua Dong; Li Li Chen; Han Dong Zhang

doi:10.3892/or_00000312

Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development

Yu Mei Ding, Ji Hua Dong, Li Li Chen, Han Dong Zhang

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Galectin-1 (Gal-1) is a newly found immunoregulatory carbohydrate-binding protein in cancer biology. The purpose of this study was to evaluate the effects of Gal-1 on oral squamous cell carcinoma (OSCC) development. Immuno-histochemistry, Western blotting and RT-PCR were carried out in 62 primary OSCC, 38 oral leukoplakia (OPL) tissues to detect the Gal-1 expression in both protein and mRNA levels. Ten normal oral mucosa (NOM) tissues were used as control. Gal-1 protein was significantly overexpressed in OSCC cancer cells and OPL prickle cells compared to NOM (P<0.05). In accordance with Gal-1 protein, Gal-1 mRNA was also up-regulated in OSCC tissues and OPL tissues. Furthermore, both the Gal-1 protein and mRNA in OSCC tissues were higher than in OPL tissues (P<0.05). Our data supports the important roles of Gal-1 in OSCC development and suggests that Gal-1 upregulation in the OSCC and OPL tissues might be a predictor of early oral carcinogenesis.

Original language	English
Pages (from-to)	983-987
Number of pages	5
Journal	Oncology Reports
Volume	21
Issue number	4
DOIs	https://doi.org/10.3892/or_00000312
State	Published - 2009
Externally published	Yes

Keywords

Galectin-1
Oral leukoplakia
Oral squamous cell carcinoma

Access to Document

10.3892/or_00000312

Cite this

@article{ebed05e7d09f4f52a7af77aa99b13d55,

title = "Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development",

abstract = "Galectin-1 (Gal-1) is a newly found immunoregulatory carbohydrate-binding protein in cancer biology. The purpose of this study was to evaluate the effects of Gal-1 on oral squamous cell carcinoma (OSCC) development. Immuno-histochemistry, Western blotting and RT-PCR were carried out in 62 primary OSCC, 38 oral leukoplakia (OPL) tissues to detect the Gal-1 expression in both protein and mRNA levels. Ten normal oral mucosa (NOM) tissues were used as control. Gal-1 protein was significantly overexpressed in OSCC cancer cells and OPL prickle cells compared to NOM (P<0.05). In accordance with Gal-1 protein, Gal-1 mRNA was also up-regulated in OSCC tissues and OPL tissues. Furthermore, both the Gal-1 protein and mRNA in OSCC tissues were higher than in OPL tissues (P<0.05). Our data supports the important roles of Gal-1 in OSCC development and suggests that Gal-1 upregulation in the OSCC and OPL tissues might be a predictor of early oral carcinogenesis.",

keywords = "Galectin-1, Oral leukoplakia, Oral squamous cell carcinoma",

author = "Ding, {Yu Mei} and Dong, {Ji Hua} and Chen, {Li Li} and Zhang, {Han Dong}",

year = "2009",

doi = "10.3892/or_00000312",

language = "English",

volume = "21",

pages = "983--987",

journal = "Oncology Reports",

issn = "1021-335X",

publisher = "Spandidos Publications",

number = "4",

}

TY - JOUR

T1 - Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development

AU - Ding, Yu Mei

AU - Dong, Ji Hua

AU - Chen, Li Li

AU - Zhang, Han Dong

PY - 2009

Y1 - 2009

N2 - Galectin-1 (Gal-1) is a newly found immunoregulatory carbohydrate-binding protein in cancer biology. The purpose of this study was to evaluate the effects of Gal-1 on oral squamous cell carcinoma (OSCC) development. Immuno-histochemistry, Western blotting and RT-PCR were carried out in 62 primary OSCC, 38 oral leukoplakia (OPL) tissues to detect the Gal-1 expression in both protein and mRNA levels. Ten normal oral mucosa (NOM) tissues were used as control. Gal-1 protein was significantly overexpressed in OSCC cancer cells and OPL prickle cells compared to NOM (P<0.05). In accordance with Gal-1 protein, Gal-1 mRNA was also up-regulated in OSCC tissues and OPL tissues. Furthermore, both the Gal-1 protein and mRNA in OSCC tissues were higher than in OPL tissues (P<0.05). Our data supports the important roles of Gal-1 in OSCC development and suggests that Gal-1 upregulation in the OSCC and OPL tissues might be a predictor of early oral carcinogenesis.

AB - Galectin-1 (Gal-1) is a newly found immunoregulatory carbohydrate-binding protein in cancer biology. The purpose of this study was to evaluate the effects of Gal-1 on oral squamous cell carcinoma (OSCC) development. Immuno-histochemistry, Western blotting and RT-PCR were carried out in 62 primary OSCC, 38 oral leukoplakia (OPL) tissues to detect the Gal-1 expression in both protein and mRNA levels. Ten normal oral mucosa (NOM) tissues were used as control. Gal-1 protein was significantly overexpressed in OSCC cancer cells and OPL prickle cells compared to NOM (P<0.05). In accordance with Gal-1 protein, Gal-1 mRNA was also up-regulated in OSCC tissues and OPL tissues. Furthermore, both the Gal-1 protein and mRNA in OSCC tissues were higher than in OPL tissues (P<0.05). Our data supports the important roles of Gal-1 in OSCC development and suggests that Gal-1 upregulation in the OSCC and OPL tissues might be a predictor of early oral carcinogenesis.

KW - Galectin-1

KW - Oral leukoplakia

KW - Oral squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=67449102212&partnerID=8YFLogxK

U2 - 10.3892/or_00000312

DO - 10.3892/or_00000312

M3 - Article

C2 - 19287997

AN - SCOPUS:67449102212

SN - 1021-335X

VL - 21

SP - 983

EP - 987

JO - Oncology Reports

JF - Oncology Reports

IS - 4

ER -

Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development

Abstract

Keywords

Access to Document

Fingerprint

Cite this