TY - JOUR
T1 - Increased erythrocyte osmotic fragility in pregnancy
AU - Magid, Margret S.
AU - Perlin, Martin
AU - Gottfried, Eugene L.
N1 - Funding Information:
Supported in part by the Arnold R. Krakower HematoIog;l; Foundation and Grants HL18828 SCOR and HLO7029 from the National Institutes of Health.
PY - 1982/12/15
Y1 - 1982/12/15
N2 - An unexpected increase in erythrocyte osmotic fragility during pregnancy in two healthy women prompted a study of the effects of pregnancy on osmotic fragility. The incubated glycerol lysis time, a rapid, sensitive measure of osmotic fragility, was determined in 100 pregnant women and 50 nonpregnant control subjects. Twenty-two of the pregnant women (22%) showed abnormal results when compared to normal nonpregnant women (p < 0.0005). Increased erythrocyte fragility was observed primarily in the last trimester of pregnancy. Twenty-one of 65 women in the last trimester (32.3%) had abnormal incubated glycerol lysis time values, but only one of 34 (2.9%) showed increased fragility during early pregnancy. Physiologic shifts in erythrocyte osmotic fragility may create a problem in the diagnosis of hereditary spherocytosis during the last trimester of pregnancy.
AB - An unexpected increase in erythrocyte osmotic fragility during pregnancy in two healthy women prompted a study of the effects of pregnancy on osmotic fragility. The incubated glycerol lysis time, a rapid, sensitive measure of osmotic fragility, was determined in 100 pregnant women and 50 nonpregnant control subjects. Twenty-two of the pregnant women (22%) showed abnormal results when compared to normal nonpregnant women (p < 0.0005). Increased erythrocyte fragility was observed primarily in the last trimester of pregnancy. Twenty-one of 65 women in the last trimester (32.3%) had abnormal incubated glycerol lysis time values, but only one of 34 (2.9%) showed increased fragility during early pregnancy. Physiologic shifts in erythrocyte osmotic fragility may create a problem in the diagnosis of hereditary spherocytosis during the last trimester of pregnancy.
UR - http://www.scopus.com/inward/record.url?scp=0020373791&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(82)90183-1
DO - 10.1016/0002-9378(82)90183-1
M3 - Article
C2 - 7148922
AN - SCOPUS:0020373791
SN - 0002-9378
VL - 144
SP - 910
EP - 914
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 8
ER -