Increased elevated plus maze open-arm time in mice during spontaneous morphine withdrawal

Sam G. Buckman; Stephen R. Hodgson; Rebecca S. Hofford; Shoshana Eitan

doi:10.1016/j.bbr.2008.09.035

Increased elevated plus maze open-arm time in mice during spontaneous morphine withdrawal

Sam G. Buckman, Stephen R. Hodgson, Rebecca S. Hofford, Shoshana Eitan

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Rats undergoing both naloxone-precipitated and spontaneous opioid withdrawal exhibit anxiogenic behaviors in the elevated plus maze (EPM). Recently, we observed an unexpected result, namely mice exhibited increased EPM open-arm time during naloxone-precipitated morphine withdrawal. This was surprising since this behavioral outcome is usually associated with an anxiolytic profile. This study demonstrates that mice exhibit an increase in both EPM open-arm time and % open-arm entries also during spontaneous opioid withdrawal.

Original language	English
Pages (from-to)	454-456
Number of pages	3
Journal	Behavioural Brain Research
Volume	197
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2008.09.035
State	Published - 11 Feb 2009
Externally published	Yes

Keywords

Anxiety
Dependence
Escape behaviors
Opioid

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10.1016/j.bbr.2008.09.035

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title = "Increased elevated plus maze open-arm time in mice during spontaneous morphine withdrawal",

abstract = "Rats undergoing both naloxone-precipitated and spontaneous opioid withdrawal exhibit anxiogenic behaviors in the elevated plus maze (EPM). Recently, we observed an unexpected result, namely mice exhibited increased EPM open-arm time during naloxone-precipitated morphine withdrawal. This was surprising since this behavioral outcome is usually associated with an anxiolytic profile. This study demonstrates that mice exhibit an increase in both EPM open-arm time and \% open-arm entries also during spontaneous opioid withdrawal.",

keywords = "Anxiety, Dependence, Escape behaviors, Opioid",

author = "Buckman, \{Sam G.\} and Hodgson, \{Stephen R.\} and Hofford, \{Rebecca S.\} and Shoshana Eitan",

note = "Funding Information: These studies were supported by NIDA (DA022402). We also would like to thank Dr. Paul Wellman for his insightful comments and Mr. Menachum M. Slodowitz for his editorial assistance. ",

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doi = "10.1016/j.bbr.2008.09.035",

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AU - Buckman, Sam G.

AU - Hodgson, Stephen R.

AU - Hofford, Rebecca S.

AU - Eitan, Shoshana

N1 - Funding Information: These studies were supported by NIDA (DA022402). We also would like to thank Dr. Paul Wellman for his insightful comments and Mr. Menachum M. Slodowitz for his editorial assistance.

PY - 2009/2/11

Y1 - 2009/2/11

N2 - Rats undergoing both naloxone-precipitated and spontaneous opioid withdrawal exhibit anxiogenic behaviors in the elevated plus maze (EPM). Recently, we observed an unexpected result, namely mice exhibited increased EPM open-arm time during naloxone-precipitated morphine withdrawal. This was surprising since this behavioral outcome is usually associated with an anxiolytic profile. This study demonstrates that mice exhibit an increase in both EPM open-arm time and % open-arm entries also during spontaneous opioid withdrawal.

AB - Rats undergoing both naloxone-precipitated and spontaneous opioid withdrawal exhibit anxiogenic behaviors in the elevated plus maze (EPM). Recently, we observed an unexpected result, namely mice exhibited increased EPM open-arm time during naloxone-precipitated morphine withdrawal. This was surprising since this behavioral outcome is usually associated with an anxiolytic profile. This study demonstrates that mice exhibit an increase in both EPM open-arm time and % open-arm entries also during spontaneous opioid withdrawal.

KW - Anxiety

KW - Dependence

KW - Escape behaviors

KW - Opioid

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EP - 456

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 2

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Increased elevated plus maze open-arm time in mice during spontaneous morphine withdrawal

Abstract

Keywords

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