Increased electrical impedance of mice following administration of scopolamine

Mice were administered either scopolamine hydrobromide (1 or 5 mg/kg, ip) or scopolamine methylbromide (1 or 5 mg/kg, ip) 15 min prior to being tested for an escape response. Scopolamine either increased or decreased escape latencies as compared to saline controls depending on the nominal shock intensity used. It also increased the electrical impedance of the mice from 10- to 20-fold. Neither of these effects was observed following administration of methylscopolamine.