Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT

N. J. Peng; R. S. Liu; J. Y. Li; D. G. Tsay; K. W. Kong; C. G. Kwok; H. W. Strauss

doi:10.1007/s002340050005

Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT

N. J. Peng
, R. S. Liu
, J. Y. Li
, D. G. Tsay
, K. W. Kong
, C. G. Kwok
, H. W. Strauss

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We report cerebral SPECT studies on two siblings with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Tc-99m HMPAO brain SPECT was performed 8, 19 and 30 days after a stroke-like episode in one case and 10 days after a strokelike episode, 6 h after a partial seizure and as a follow-up study in the other. Increased blood flow was seen in both these patients with stroke-like episodes due to MELAS. The cause of the increased blood flow is uncertain, but it may be related to the decreased pH created by local increase in lactic acid.

Original language	English
Pages (from-to)	26-29
Number of pages	4
Journal	Neuroradiology
Volume	42
Issue number	1
DOIs	https://doi.org/10.1007/s002340050005
State	Published - Jan 2000
Externally published	Yes

Keywords

MELAS
Single-photon emission computed tomography Cerebral blood flow

Access to Document

10.1007/s002340050005

Cite this

@article{097e5355ae0d499399363e615c3c1704,

title = "Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT",

abstract = "We report cerebral SPECT studies on two siblings with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Tc-99m HMPAO brain SPECT was performed 8, 19 and 30 days after a stroke-like episode in one case and 10 days after a strokelike episode, 6 h after a partial seizure and as a follow-up study in the other. Increased blood flow was seen in both these patients with stroke-like episodes due to MELAS. The cause of the increased blood flow is uncertain, but it may be related to the decreased pH created by local increase in lactic acid.",

keywords = "MELAS, Single-photon emission computed tomography Cerebral blood flow",

author = "Peng, \{N. J.\} and Liu, \{R. S.\} and Li, \{J. Y.\} and Tsay, \{D. G.\} and Kong, \{K. W.\} and Kwok, \{C. G.\} and Strauss, \{H. W.\}",

year = "2000",

month = jan,

doi = "10.1007/s002340050005",

language = "English",

volume = "42",

pages = "26--29",

journal = "Neuroradiology",

issn = "0028-3940",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "1",

}

TY - JOUR

T1 - Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT

AU - Peng, N. J.

AU - Liu, R. S.

AU - Li, J. Y.

AU - Tsay, D. G.

AU - Kong, K. W.

AU - Kwok, C. G.

AU - Strauss, H. W.

PY - 2000/1

Y1 - 2000/1

N2 - We report cerebral SPECT studies on two siblings with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Tc-99m HMPAO brain SPECT was performed 8, 19 and 30 days after a stroke-like episode in one case and 10 days after a strokelike episode, 6 h after a partial seizure and as a follow-up study in the other. Increased blood flow was seen in both these patients with stroke-like episodes due to MELAS. The cause of the increased blood flow is uncertain, but it may be related to the decreased pH created by local increase in lactic acid.

AB - We report cerebral SPECT studies on two siblings with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Tc-99m HMPAO brain SPECT was performed 8, 19 and 30 days after a stroke-like episode in one case and 10 days after a strokelike episode, 6 h after a partial seizure and as a follow-up study in the other. Increased blood flow was seen in both these patients with stroke-like episodes due to MELAS. The cause of the increased blood flow is uncertain, but it may be related to the decreased pH created by local increase in lactic acid.

KW - MELAS

KW - Single-photon emission computed tomography Cerebral blood flow

UR - https://www.scopus.com/pages/publications/0034000525

U2 - 10.1007/s002340050005

DO - 10.1007/s002340050005

M3 - Article

C2 - 10663465

AN - SCOPUS:0034000525

SN - 0028-3940

VL - 42

SP - 26

EP - 29

JO - Neuroradiology

JF - Neuroradiology

IS - 1

ER -

Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT

Abstract

Keywords

Access to Document

Fingerprint

Cite this