Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT

N. J. Peng; R. S. Liu; J. Y. Li; D. G. Tsay; K. W. Kong; C. G. Kwok; H. W. Strauss

doi:10.1007/s002340050005

Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT

N. J. Peng, R. S. Liu, J. Y. Li, D. G. Tsay, K. W. Kong, C. G. Kwok, H. W. Strauss

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21 Scopus citations

Abstract

We report cerebral SPECT studies on two siblings with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Tc-99m HMPAO brain SPECT was performed 8, 19 and 30 days after a stroke-like episode in one case and 10 days after a strokelike episode, 6 h after a partial seizure and as a follow-up study in the other. Increased blood flow was seen in both these patients with stroke-like episodes due to MELAS. The cause of the increased blood flow is uncertain, but it may be related to the decreased pH created by local increase in lactic acid.

Original language	English
Pages (from-to)	26-29
Number of pages	4
Journal	Neuroradiology
Volume	42
Issue number	1
DOIs	https://doi.org/10.1007/s002340050005
State	Published - Jan 2000
Externally published	Yes

Keywords

MELAS
Single-photon emission computed tomography Cerebral blood flow

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title = "Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT",

abstract = "We report cerebral SPECT studies on two siblings with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Tc-99m HMPAO brain SPECT was performed 8, 19 and 30 days after a stroke-like episode in one case and 10 days after a strokelike episode, 6 h after a partial seizure and as a follow-up study in the other. Increased blood flow was seen in both these patients with stroke-like episodes due to MELAS. The cause of the increased blood flow is uncertain, but it may be related to the decreased pH created by local increase in lactic acid.",

keywords = "MELAS, Single-photon emission computed tomography Cerebral blood flow",

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AU - Peng, N. J.

AU - Liu, R. S.

AU - Li, J. Y.

AU - Tsay, D. G.

AU - Kong, K. W.

AU - Kwok, C. G.

AU - Strauss, H. W.

PY - 2000/1

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N2 - We report cerebral SPECT studies on two siblings with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Tc-99m HMPAO brain SPECT was performed 8, 19 and 30 days after a stroke-like episode in one case and 10 days after a strokelike episode, 6 h after a partial seizure and as a follow-up study in the other. Increased blood flow was seen in both these patients with stroke-like episodes due to MELAS. The cause of the increased blood flow is uncertain, but it may be related to the decreased pH created by local increase in lactic acid.

AB - We report cerebral SPECT studies on two siblings with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Tc-99m HMPAO brain SPECT was performed 8, 19 and 30 days after a stroke-like episode in one case and 10 days after a strokelike episode, 6 h after a partial seizure and as a follow-up study in the other. Increased blood flow was seen in both these patients with stroke-like episodes due to MELAS. The cause of the increased blood flow is uncertain, but it may be related to the decreased pH created by local increase in lactic acid.

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Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT

Abstract

Keywords

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