Increased accumulation of 2-deoxy-2-[ 18F]fluoro-D-glucose in liver metastases from colon carcinoma

Y. Yonekura; R. S. Benua; A. B. Brill; P. Som; S. D. Yeh; N. E. Kemeny; J. S. Fowler; R. R. MacGregor; R. Stamm; D. R. Christman; A. P. Wolf

Increased accumulation of 2-deoxy-2-[ ¹⁸F]fluoro-D-glucose in liver metastases from colon carcinoma

Y. Yonekura
, R. S. Benua
, A. B. Brill
, P. Som
, S. D. Yeh
, N. E. Kemeny
, J. S. Fowler
, R. R. MacGregor
, R. Stamm
, D. R. Christman
, A. P. Wolf

Research output: Contribution to journal › Article › peer-review

206 Scopus citations

Abstract

Three patients with liver metastases from colon carcinoma were studied with 2-deoxy-2-[F-18]fluoro-D-glucose (F-18-FDG) using positron emission tomography. The radioactivity in the metastatic tumor increased continuously following the injection of F-18-FDG, whereas it decreased in normal liver tissue. This resulted in the tumor to normal-liver ratio of 3.3-4.7 at 50 min after injection. The liver tumor was visualized as an increased accumulation of radioactivity in all patients, with the central area of the tumor showing less activity. These preliminary results suggest that F-18-FDG may be useful as a positive imaging agent for the detection and characterization of liver tumors.

Original language	English
Pages (from-to)	1133-1137
Number of pages	5
Journal	Journal of Nuclear Medicine
Volume	23
Issue number	12
State	Published - 1982

Cite this

@article{240e76a3bba34304aed0022078bc0785,

title = "Increased accumulation of 2-deoxy-2-[ 18F]fluoro-D-glucose in liver metastases from colon carcinoma",

abstract = "Three patients with liver metastases from colon carcinoma were studied with 2-deoxy-2-[F-18]fluoro-D-glucose (F-18-FDG) using positron emission tomography. The radioactivity in the metastatic tumor increased continuously following the injection of F-18-FDG, whereas it decreased in normal liver tissue. This resulted in the tumor to normal-liver ratio of 3.3-4.7 at 50 min after injection. The liver tumor was visualized as an increased accumulation of radioactivity in all patients, with the central area of the tumor showing less activity. These preliminary results suggest that F-18-FDG may be useful as a positive imaging agent for the detection and characterization of liver tumors.",

author = "Y. Yonekura and Benua, \{R. S.\} and Brill, \{A. B.\} and P. Som and Yeh, \{S. D.\} and Kemeny, \{N. E.\} and Fowler, \{J. S.\} and MacGregor, \{R. R.\} and R. Stamm and Christman, \{D. R.\} and Wolf, \{A. P.\}",

year = "1982",

language = "English",

volume = "23",

pages = "1133--1137",

journal = "Journal of Nuclear Medicine",

issn = "0161-5505",

publisher = "Society of Nuclear Medicine Inc.",

number = "12",

}

TY - JOUR

T1 - Increased accumulation of 2-deoxy-2-[ 18F]fluoro-D-glucose in liver metastases from colon carcinoma

AU - Yonekura, Y.

AU - Benua, R. S.

AU - Brill, A. B.

AU - Som, P.

AU - Yeh, S. D.

AU - Kemeny, N. E.

AU - Fowler, J. S.

AU - MacGregor, R. R.

AU - Stamm, R.

AU - Christman, D. R.

AU - Wolf, A. P.

PY - 1982

Y1 - 1982

N2 - Three patients with liver metastases from colon carcinoma were studied with 2-deoxy-2-[F-18]fluoro-D-glucose (F-18-FDG) using positron emission tomography. The radioactivity in the metastatic tumor increased continuously following the injection of F-18-FDG, whereas it decreased in normal liver tissue. This resulted in the tumor to normal-liver ratio of 3.3-4.7 at 50 min after injection. The liver tumor was visualized as an increased accumulation of radioactivity in all patients, with the central area of the tumor showing less activity. These preliminary results suggest that F-18-FDG may be useful as a positive imaging agent for the detection and characterization of liver tumors.

AB - Three patients with liver metastases from colon carcinoma were studied with 2-deoxy-2-[F-18]fluoro-D-glucose (F-18-FDG) using positron emission tomography. The radioactivity in the metastatic tumor increased continuously following the injection of F-18-FDG, whereas it decreased in normal liver tissue. This resulted in the tumor to normal-liver ratio of 3.3-4.7 at 50 min after injection. The liver tumor was visualized as an increased accumulation of radioactivity in all patients, with the central area of the tumor showing less activity. These preliminary results suggest that F-18-FDG may be useful as a positive imaging agent for the detection and characterization of liver tumors.

UR - https://www.scopus.com/pages/publications/0020444121

M3 - Article

C2 - 6982967

AN - SCOPUS:0020444121

SN - 0161-5505

VL - 23

SP - 1133

EP - 1137

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 12

ER -

Increased accumulation of 2-deoxy-2-[ 18F]fluoro-D-glucose in liver metastases from colon carcinoma

Abstract

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Increased accumulation of 2-deoxy-2-[ ¹⁸F]fluoro-D-glucose in liver metastases from colon carcinoma