Incident CHD and ischemic stroke associated with lipoprotein(a) by levels of Factor VIII and inflammation

Lisandro D. Colantonio, Sascha N. Goonewardena, Zhixin Wang, Elizabeth A. Jackson, Michael E. Farkouh, Mei Li, Waqas Malick, Shia T. Kent, J. Antonio G. López, Paul Muntner, Vera Bittner, Robert S. Rosenson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Inflammation and coagulation may contribute to the increased risk for atherosclerotic cardiovascular disease (ASCVD) associated with high lipoprotein(a). The association of lipoprotein(a) with ASCVD is stronger in individuals with high versus low high-sensitivity C-reactive protein (hs-CRP), a marker of inflammation. Objectives: Determine the association of lipoprotein(a) with incident ASCVD by levels of coagulation Factor VIII controlling for hs-CRP. Methods: We analyzed data from 6,495 men and women 45 to 84 years of age in the Multi-Ethnic Study of Atherosclerosis (MESA) without prevalent ASCVD at baseline (2000-2002). Lipoprotein(a) mass concentration, Factor VIII coagulant activity, and hs-CRP were measured at baseline and categorized as high or low (≥75th or <75th percentile of the distribution). Participants were followed for incident coronary heart disease (CHD) and ischemic stroke through 2015. Results: Over a median follow-up of 13.9 years, there were 390 CHD and 247 ischemic stroke events. The hazard ratio (95%CI) for CHD associated with high lipoprotein(a) (≥40.1 versus <40.1 mg/dL) including adjustment for hs-CRP among participants with low and high Factor VIII was 1.07 (0.80-1.44) and 2.00 (1.33-3.01), respectively (p-value for interaction 0.016). The hazard ratio (95%CI) for CHD associated with high lipoprotein(a) including adjustment for Factor VIII was 1.16 (0.87-1.54) and 2.00 (1.29-3.09) among participants with low and high hs-CRP, respectively (p-value for interaction 0.042). Lp(a) was not associated with ischemic stroke regardless of Factor VIII or hs-CRP levels. Conclusion: High lipoprotein(a) is a risk factor for CHD in adults with high levels of hemostatic or inflammatory markers.

Original languageEnglish
Pages (from-to)529-537
Number of pages9
JournalJournal of Clinical Lipidology
Volume17
Issue number4
DOIs
StatePublished - 1 Jul 2023

Keywords

  • Adults
  • Blood coagulation
  • Coronary heart disease
  • Inflammation
  • Lipoprotein(a)
  • Stroke

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