Incidence, Outcomes, and Opportunity for Left Ventricular Assist Device Weaning for Myocardial Recovery

Shinobu Itagaki, Noah Moss, Nana Toyoda, Donna Mancini, Natalia Egorova, Gregory Serrao, Anuradha Lala, Sean P. Pinney, Percy Boateng, David H. Adams, Anelechi C. Anyanwu

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Myocardial recovery occurs in patients with advanced heart failure on left ventricular assist device (LVAD) support, but there is the premise that it is rare with uncertain results. Objectives: The goal of this study was to investigate the incidence and consequence of LVAD explant after myocardial recovery. Methods: Using the United Network for Organ Sharing registry, LVAD implants in the United States between 2005 and 2020 were tracked until death, transplantation, or explant for myocardial recovery. The cohort undergoing explant was followed up for heart failure relapse (defined as relisting followed by delisting due to death, being too ill, or transplantation; or second durable LVAD implant). Results: Of 15,728 LVAD implants, 126 patients underwent explant for recovery, which only occurred in 55 (38%) of 145 implanting centers. The crude cumulative incidence was 0.7% at 2 years, whereas the incidence reached 4.7% among designated centers in the selected young nonischemic cohort. Of 126 explanted patients, 76 (60%) were subsequently delisted for sustained recovery. Heart failure relapsing had a relatively higher hazard in the early phase, with a 30-day incidence of 6% (7 of 126) but tapered following with the freedom rate of 72.5% at 4 years. Conclusions: In the United States, LVAD explant for myocardial recovery was underutilized, leading to a very low incidence at the national level despite a realistic rate being achieved in designated centers for selected patients. With follow-up extending up to 4 years after explant, more than one-half were successfully removed and stayed off the waitlist, and approximately 70% were free from heart failure relapse events.

Original languageEnglish
JournalJACC: Heart Failure
DOIs
StateAccepted/In press - 2024

Keywords

  • end-stage heart failure
  • left ventricular assist device
  • myocardial recovery

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