Incidence of multiple primary cancers in a cohort of women diagnosed with breast cancer in southeast England

H. S. Evans, C. M. Lewis, D. Robinson, C. M.J. Bell, H. Moller, S. V. Hodgson

Research output: Contribution to journalArticlepeer-review

107 Scopus citations

Abstract

Among women in the Thames Cancer Registry database with a first breast cancer diagnosed between 1961-1995 observed numbers of subsequent cancers were compared with expected numbers and standardized incidence ratios were calculated. The occurrence of breast cancers subsequent to cancers at other sites was also examined. Women diagnosed with breast cancer before age 50 had significantly elevated risks for 9 cancer sites namely, oesophagus, stomach, lung, bone, connective tissue, breast, corpus uteri, ovary and myeloid leukaemia compared with 2 sites (corpus uteri and myeloid leukaemia) in women diagnosed at age 50 and above. Some of these associations are consistent with the effects of known inherited cancer susceptibility genes, shared environmental factors, or therapy.

Original languageEnglish
Pages (from-to)435-440
Number of pages6
JournalBritish Journal of Cancer
Volume84
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Breast cancer
  • Cancer genetics
  • Multiple primary cancers
  • Registries

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