Incidence of mild cognitive impairment in World Trade Center responders: Long-term consequences of re-experiencing the events on 9/11/2001

Sean A.P. Clouston; Erica D. Diminich; Roman Kotov; Robert H. Pietrzak; Marcus Richards; Avron Spiro; Yael Deri; Melissa Carr; Xiaohua Yang; Sam Gandy; Mary Sano; Evelyn J. Bromet; Benjamin J. Luft

doi:10.1016/j.dadm.2019.07.006

Incidence of mild cognitive impairment in World Trade Center responders: Long-term consequences of re-experiencing the events on 9/11/2001

Sean A.P. Clouston, Erica D. Diminich, Roman Kotov, Robert H. Pietrzak, Marcus Richards, Avron Spiro, Yael Deri, Melissa Carr, Xiaohua Yang, Sam Gandy, Mary Sano, Evelyn J. Bromet, Benjamin J. Luft

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Objective: This study examined whether World Trade Center (WTC) exposures and chronic posttraumatic stress disorder (PTSD) were associated with incidence of mild cognitive impairment (MCI) in a longitudinal analysis of a prospective cohort study of WTC responders. Methods: Incidence of MCI was assessed in a clinical sample of WTC responders (N = 1800) who were cognitively intact at baseline assessment. Crude incidence rates were calculated and compared to population estimates using standardized incidence ratios. Multivariable analyses used Cox proportional-hazards regression. Results: Responders were 53.1 years old (SD = 7.9) at baseline. Among eligible cognitively intact responders, 255 (14.2%) developed MCI at follow-up. Incidence of MCI was higher than expected based on expectations from prior published research. Incidence was higher among those with increased PTSD symptom severity, and prolonged exposure was a risk factor in apolipoprotein-ε4 carriers. Conclusions: PTSD and prolonged WTC exposures were associated with increased incidence of MCI in WTC responders, results that may portend future high rates of dementia in WTC-exposed responders.

Original language	English
Pages (from-to)	628-636
Number of pages	9
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	11
DOIs	https://doi.org/10.1016/j.dadm.2019.07.006
State	Published - Dec 2019

Keywords

Mild cognitive impairment
Posttraumatic stress
World Trade Center disaster

Access to Document

10.1016/j.dadm.2019.07.006

Cite this

Clouston, S. A. P., Diminich, E. D., Kotov, R., Pietrzak, R. H., Richards, M., Spiro, A., Deri, Y., Carr, M., Yang, X., Gandy, S., Sano, M., Bromet, E. J., & Luft, B. J. (2019). Incidence of mild cognitive impairment in World Trade Center responders: Long-term consequences of re-experiencing the events on 9/11/2001. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11, 628-636. https://doi.org/10.1016/j.dadm.2019.07.006

@article{4fc9127460b6454d8f6947a1b353d5ad,

title = "Incidence of mild cognitive impairment in World Trade Center responders: Long-term consequences of re-experiencing the events on 9/11/2001",

abstract = "Objective: This study examined whether World Trade Center (WTC) exposures and chronic posttraumatic stress disorder (PTSD) were associated with incidence of mild cognitive impairment (MCI) in a longitudinal analysis of a prospective cohort study of WTC responders. Methods: Incidence of MCI was assessed in a clinical sample of WTC responders (N = 1800) who were cognitively intact at baseline assessment. Crude incidence rates were calculated and compared to population estimates using standardized incidence ratios. Multivariable analyses used Cox proportional-hazards regression. Results: Responders were 53.1 years old (SD = 7.9) at baseline. Among eligible cognitively intact responders, 255 (14.2%) developed MCI at follow-up. Incidence of MCI was higher than expected based on expectations from prior published research. Incidence was higher among those with increased PTSD symptom severity, and prolonged exposure was a risk factor in apolipoprotein-ε4 carriers. Conclusions: PTSD and prolonged WTC exposures were associated with increased incidence of MCI in WTC responders, results that may portend future high rates of dementia in WTC-exposed responders.",

keywords = "Mild cognitive impairment, Posttraumatic stress, World Trade Center disaster",

author = "Clouston, {Sean A.P.} and Diminich, {Erica D.} and Roman Kotov and Pietrzak, {Robert H.} and Marcus Richards and Avron Spiro and Yael Deri and Melissa Carr and Xiaohua Yang and Sam Gandy and Mary Sano and Bromet, {Evelyn J.} and Luft, {Benjamin J.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = dec,

doi = "10.1016/j.dadm.2019.07.006",

language = "English",

volume = "11",

pages = "628--636",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

issn = "2352-8729",

publisher = "John Wiley and Sons Inc.",

}

Clouston, SAP, Diminich, ED, Kotov, R, Pietrzak, RH, Richards, M, Spiro, A, Deri, Y, Carr, M, Yang, X, Gandy, S , Sano, M, Bromet, EJ & Luft, BJ 2019, 'Incidence of mild cognitive impairment in World Trade Center responders: Long-term consequences of re-experiencing the events on 9/11/2001', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 11, pp. 628-636. https://doi.org/10.1016/j.dadm.2019.07.006

Incidence of mild cognitive impairment in World Trade Center responders: Long-term consequences of re-experiencing the events on 9/11/2001. / Clouston, Sean A.P.; Diminich, Erica D.; Kotov, Roman et al.
In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 12.2019, p. 628-636.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Incidence of mild cognitive impairment in World Trade Center responders

T2 - Long-term consequences of re-experiencing the events on 9/11/2001

AU - Clouston, Sean A.P.

AU - Diminich, Erica D.

AU - Kotov, Roman

AU - Pietrzak, Robert H.

AU - Richards, Marcus

AU - Spiro, Avron

AU - Deri, Yael

AU - Carr, Melissa

AU - Yang, Xiaohua

AU - Gandy, Sam

AU - Sano, Mary

AU - Bromet, Evelyn J.

AU - Luft, Benjamin J.

PY - 2019/12

Y1 - 2019/12

N2 - Objective: This study examined whether World Trade Center (WTC) exposures and chronic posttraumatic stress disorder (PTSD) were associated with incidence of mild cognitive impairment (MCI) in a longitudinal analysis of a prospective cohort study of WTC responders. Methods: Incidence of MCI was assessed in a clinical sample of WTC responders (N = 1800) who were cognitively intact at baseline assessment. Crude incidence rates were calculated and compared to population estimates using standardized incidence ratios. Multivariable analyses used Cox proportional-hazards regression. Results: Responders were 53.1 years old (SD = 7.9) at baseline. Among eligible cognitively intact responders, 255 (14.2%) developed MCI at follow-up. Incidence of MCI was higher than expected based on expectations from prior published research. Incidence was higher among those with increased PTSD symptom severity, and prolonged exposure was a risk factor in apolipoprotein-ε4 carriers. Conclusions: PTSD and prolonged WTC exposures were associated with increased incidence of MCI in WTC responders, results that may portend future high rates of dementia in WTC-exposed responders.

AB - Objective: This study examined whether World Trade Center (WTC) exposures and chronic posttraumatic stress disorder (PTSD) were associated with incidence of mild cognitive impairment (MCI) in a longitudinal analysis of a prospective cohort study of WTC responders. Methods: Incidence of MCI was assessed in a clinical sample of WTC responders (N = 1800) who were cognitively intact at baseline assessment. Crude incidence rates were calculated and compared to population estimates using standardized incidence ratios. Multivariable analyses used Cox proportional-hazards regression. Results: Responders were 53.1 years old (SD = 7.9) at baseline. Among eligible cognitively intact responders, 255 (14.2%) developed MCI at follow-up. Incidence of MCI was higher than expected based on expectations from prior published research. Incidence was higher among those with increased PTSD symptom severity, and prolonged exposure was a risk factor in apolipoprotein-ε4 carriers. Conclusions: PTSD and prolonged WTC exposures were associated with increased incidence of MCI in WTC responders, results that may portend future high rates of dementia in WTC-exposed responders.

KW - Mild cognitive impairment

KW - Posttraumatic stress

KW - World Trade Center disaster

UR - http://www.scopus.com/inward/record.url?scp=85071888128&partnerID=8YFLogxK

U2 - 10.1016/j.dadm.2019.07.006

DO - 10.1016/j.dadm.2019.07.006

M3 - Article

AN - SCOPUS:85071888128

SN - 2352-8729

VL - 11

SP - 628

EP - 636

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

ER -

Incidence of mild cognitive impairment in World Trade Center responders: Long-term consequences of re-experiencing the events on 9/11/2001

Abstract

Keywords

Access to Document

Fingerprint

Cite this